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dc.contributor.authorElito, Julio [UNIFESP]
dc.contributor.authorDaher, Silvia [UNIFESP]
dc.contributor.authorFernandes da Silva, Marcelo Octavio [UNIFESP]
dc.contributor.authorHigashi Marconi, Natali Maiumi [UNIFESP]
dc.contributor.authorTezotto Pendeloski, Karen Priscilla [UNIFESP]
dc.contributor.authorMoron, Antonio Fernandes [UNIFESP]
dc.contributor.authorCamano, Luiz [UNIFESP]
dc.identifier.citationAmerican Journal of Reproductive Immunology. Malden: Wiley-Blackwell, v. 63, n. 2, p. 120-125, 2010.
dc.description.abstractProblemIn ectopic pregnancy, increased levels of vascular endothelial growth factor are present. the aims of this study were to determine the association between -634C/G, -460T/C, and +936C/T vascular endothelial growth factor (VEGF) polymorphisms and ectopic pregnancy, and to determine whether serum levels of VEGF were affected by genetic factors.Method of studyThis is a case-control study wherein 74 women with a history of ectopic pregnancy in a tertiary care center were compared to 134 post-menopausal controls with two pregnancies and no ectopic pregnancy for the genotyping of VEGF polymorphisms. for 35 patients with the diagnosis of ectopic pregnancy, serum concentrations of VEGF were obtained before the treatment. Genotyping of VEGF (-634C/G, -460T/C, and +936C/T) polymorphisms was performed by PCR, followed by endonuclease digestion. ELISA was performed to evaluate the VEGF serum levels.ResultsThe -634C/G, -460T/C, and +936C/T VEGF polymorphisms were not associated with ectopic pregnancy (P = 0.170, P = 0.285, and P = 0.700, respectively). the serum levels of VEGF were not associated with the genotype of -634C/G, -460T/C, and +936C/T VEGF polymorphisms (P = 0.702; P = 0.347, and P = 0.256, respectively).ConclusionThere was no association between ectopic pregnancy and -634C/G, -460T/C, and +936C/T VEGF polymorphisms. There was no correlation between VEGF genotype and the expression of VEGF in blood samples.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.relation.ispartofAmerican Journal of Reproductive Immunology
dc.rightsAcesso restrito
dc.subjectEctopic pregnancyen
dc.titleAssociation Study of Vascular Endothelial Growth Factor and Polymorphisms of its Gene with Ectopic Pregnancyen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniversidade Federal de São Paulo, Dept Obstet, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Obstet, São Paulo, Brazil
dc.description.sourceWeb of Science
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