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Title: Violence and post-traumatic stress disorder in São Paulo and Rio de Janeiro, Brazil: the protocol for an epidemiological and genetic survey
Authors: Andreoli, Sergio Baxter [UNIFESP]
Ribeiro, Wagner Silva [UNIFESP]
Quintana, Maria Inês [UNIFESP]
Guindalini, Camila [UNIFESP]
Breen, Gerome
Blay, Sergio Luis [UNIFESP]
Coutinho, Evandro S. F.
Harpham, Trudy
Jorge, Miguel Roberto [UNIFESP]
Lara, Diogo Rizzato
Moriyama, Tais Silveira [UNIFESP]
Quarantini, Lucas de Castro [UNIFESP]
Gadelha, Ary [UNIFESP]
Vilete, Liliane Maria Pereira
Yeh, Mary Sau Ling [UNIFESP]
Prince, Martin
Figueira, Ivan
Bressan, Rodrigo Affonseca [UNIFESP]
Mello, Marcelo Feijó de [UNIFESP]
Dewey, Michael E.
Ferri, Cleusa P.
Mari, Jair de Jesus [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Kings Coll London
London S Bank Univ
London Sch Hyg & Trop Med
Pontificia Univ Catolica Rio Grande do Sul
Univ London
Universidade Federal do Rio de Janeiro (UFRJ)
Issue Date: 7-Jun-2009
Publisher: Biomed Central Ltd
Citation: Bmc Psychiatry. London: Biomed Central Ltd, v. 9, 9 p., 2009.
Abstract: Background: violence is a public health major concern, and it is associated with post-traumatic stress disorder and other psychiatric outcomes. Brazil is one of the most violent countries in the world, and has an extreme social inequality. Research on the association between violence and mental health may support public health policy and thus reduce the burden of disease attributable to violence. the main objectives of this project were: to study the association between violence and mental disorders in the Brazilian population; to estimate the prevalence rates of exposure to violence, post-traumatic stress disorder, common metal disorder, and alcohol hazardous use and dependence: and to identify contextual and individual factors, including genetic factors, associated with the outcomes.Methods/design: one phase cross-sectional survey carried out in São Paulo and Rio de Janeiro, Brazil. A multistage probability to size sampling scheme was performed in order to select the participants (3000 and 1500 respectively). the cities were stratified according to homicide rates, and in São Paulo the three most violent strata were oversampled. the measurements included exposure to traumatic events, psychiatric diagnoses (CIDI 2.1), contextual (homicide rates and social indicators), and individual factors, such as demographics, social capital, resilience, help seeking behaviours. the interviews were carried between June/2007 February/2008, by a team of lay interviewers. the statistical analyses will be weight-adjusted in order to take account of the design effects. Standardization will be used in order to compare the results between the two centres. Whole genome association analysis will be performed on the 1 million SNP (single nucleotide polymorphism) arrays, and additional association analysis will be performed on additional phenotypes. the Ethical Committee of the Federal University of São Paulo approved the study, and participants who matched diagnostic criteria have been offered a referral to outpatient clinics at the Federal University of São Paulo and Federal University of Rio de Janeiro.
ISSN: 1471-244X
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