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Title: Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth in Vitro and in Vivo
Authors: Lopes, Stefanie C. P.
Blanco, Yara C.
Justo, Giselle Z. [UNIFESP]
Nogueira, Paulo A.
Rodrigues, Francisco L. S.
Goelnitz, Uta
Wunderlich, Gerhard
Facchini, Gustavo
Brocchi, Marcelo
Duran, Nelson
Costa, Fabio Trindade Maranhão [UNIFESP]
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Issue Date: 1-May-2009
Publisher: Amer Soc Microbiology
Citation: Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 53, n. 5, p. 2149-2152, 2009.
Abstract: Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudi-infected mice from a lethal challenge.
ISSN: 0066-4804
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Appears in Collections:Artigo

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