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Title: Low urinary 6-sulphatoxymelatonin concentrations in acute migraine
Authors: Masruha, Marcelo Rodrigues [UNIFESP]
Vieira, Domingos Sávio de Souza [UNIFESP]
Minett, Thaís Soares Cianciarullo [UNIFESP]
Cipolla-Neto, Jose
Zukerman, Eliova [UNIFESP]
Vilanova, Luiz Celso Pereira [UNIFESP]
Peres, Mario Fernando Prieto [UNIFESP]
Hosp Israelita Albert Einstein
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Keywords: Circadian rhythm
Issue Date: 1-Aug-2008
Publisher: Springer
Citation: Journal of Headache and Pain. New York: Springer, v. 9, n. 4, p. 221-224, 2008.
Abstract: Substantial evidence points to melatonin as playing a role in the regulation of circadian rhythms, sleep, and headache disorders. the objective of the study was to assess 6-sulphatoxymelatonin (aMT6s) levels in a large consecutive series of patients with migraine, comparing with controls. A total of 220 subjects were evaluated-146 had migraine and 74 were control subjects. Urinary samples were collected into the same plastic container since 8:00 p.m. to 8:00 a.m. of the next day (12-h period) and aMT6s was measured with quantitative ELISA technique. Among patients with migraine, 53% presented pain on the day of the urine samples collection. Their urinary aMT6s concentration was significantly lower than in the urine of patients without pain [14.0 +/- 7.3 vs. 49.4 +/- 19.0; t(143) = -15.1; 95% CI = -40.0 to -30.8; P<0.001]. There was no significant difference in the aMT6s concentration of patients with migraine without pain on the day of their urine samples collection and controls [49.4 +/- 19.0 vs. 42.5 +/- 27.9; t(140) = 1.7; 95% CI = -1.2 to 14.8; P = 0.094]. To our knowledge, this is the first study to demonstrate reduction in melatonin levels during attacks in episodic and chronic migraine.
ISSN: 1129-2369
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