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Title: Biomarkers of oxidative stress and antioxidant status in children born small for gestational age: Evidence of lipid peroxidation
Authors: Franco, Maria do Carmo Pinho [UNIFESP]
Kawamoto, Elisa M.
Gorjao, Renata
Rastelli, Viviani M. F.
Curi, Rui
Scavone, Cristoforo
Sawaya, Ana Lydia [UNIFESP]
Fortes, Zuleica Bruno
Sesso, Ricardo de Castro Cintra [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Issue Date: 1-Aug-2007
Publisher: Int Pediatric Research Foundation, Inc
Citation: Pediatric Research. Baltimore: Int Pediatric Research Foundation, Inc, v. 62, n. 2, p. 204-208, 2007.
Abstract: Children born small for gestational age are known to be at increased risk for adult diseases such as hypertension, diabetes, and coronary heart disease. Oxidative stress is a common feature of these pathogenic conditions and can be the key link between size at birth and increased morbidity later in life. the purpose of this study was to analyze the parameters of lipoperoxidation and changes in antioxidant defense system as well as assess their relationship to birth weight. Concentrations of thiobarbituric-acid-reactive-substances and F-2-isoprostanes, total antioxidant status, and the activity of both superoxide dismutase and glutathione peroxidase were measured in 65 children (33 boys, 32 girls; ages 8-13 y). Thiobarbituric-acid-reactive-substances and F-2-isoprostane levels were significantly elevated in children born small for gestational age. Nevertheless, superoxide dismutase activity was significantly elevated in these children and the levels of both glutathione peroxidase activity and total antioxidant status were unchanged. Moreover, we found that systolic blood pressure was positively associated with thiobarbituric-acid-reactive-substances levels in race- and gender-adjusted models but not in a multivariable regression model. in conclusion, the current study revealed that there is evidence of oxidative stress in children born small for gestational age as supported by increased lipid peroxidation.
ISSN: 0031-3998
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Appears in Collections:Em verificação - Geral

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