Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/29889
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dc.contributor.authorFranco, Maria do Carmo Pinho [UNIFESP]
dc.contributor.authorHiga, Elisa Mieko Suemitsu [UNIFESP]
dc.contributor.authorD'Almeida, Vânia [UNIFESP]
dc.contributor.authorSousa, Fernanda G. de [UNIFESP]
dc.contributor.authorSawaya, Ana Lydia [UNIFESP]
dc.contributor.authorFortes, Zuleica B.
dc.contributor.authorSesso, Ricardo de Castro Cintra [UNIFESP]
dc.date.accessioned2016-01-24T13:48:53Z-
dc.date.available2016-01-24T13:48:53Z-
dc.date.issued2007-08-01
dc.identifierhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.107.091223
dc.identifier.citationHypertension. Philadelphia: Lippincott Williams & Wilkins, v. 50, n. 2, p. 396-402, 2007.
dc.identifier.issn0194-911X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29889-
dc.description.abstractLeptin, homocysteine (Hcy), and C-reactive protein are risk factors potentially useful in predicting future cardiac events. These plasma biomarkers may participate in the regulation of cardiovascular function through an NO- dependent mechanism. Our purpose was to investigate whether alterations in C-reactive protein, Hcy, leptin, and NO are present in small-for-gestational-age children and to determine whether the levels of these plasma biomarkers are associated with birth weight, vascular function, and blood pressure. Concentrations of leptin, Hcy, C- reactive protein, and NO were measured in 69 children (36 boys and 33 girls; ages 8 to 13 years). Leptin (means difference: 1.4 ng/mL; 95% CI: 0.4 to 2.4) and Hcy (means difference: 0.9 mu mol/L; 95% CI: 0.3 to 1.5) levels were significantly elevated in children born small for gestational age compared with those with appropriate birth weight. Nevertheless, NO (means difference: 342.9 mu mol; 95% CI: 124.2 to 561.6) concentration was significantly reduced in small birth weight children, and the levels of C- reactive protein remained unchanged. There was a significant association between the circulating levels of both NO and Hcy with vascular function, as well as with blood pressure levels, in our population. Because both Hcy and NO are associated with a risk of cardiovascular disease, it is possible that part of the association of low birth weight with elevated risk for vascular and metabolic disease in later life is mediated by perturbation in pathways for these biomarkers.en
dc.format.extent396-402
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofHypertension
dc.rightsAcesso aberto
dc.subjecthomocysteineen
dc.subjectNOen
dc.subjectendothelium functionen
dc.subjectblood pressureen
dc.subjectchildrenen
dc.titleHomocysteine and nitric oxide are related to blood pressure and vascular function in small-for-gestational-age childrenen
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUniversidade Federal de São Paulo, Div Nephrol, Sch Med, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Div Genet, Sch Med, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, Sch Med, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Pharmacol, Biomed Sci Inst, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Nephrol, Sch Med, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Genet, Sch Med, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, Sch Med, BR-04023900 São Paulo, Brazil
dc.identifier.doi10.1161/HYPERTENSIONAHA.107.091223
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000248176400023
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