Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/29873
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dc.contributor.authorEgima, Claudia M. [UNIFESP]
dc.contributor.authorMacedo, Silene F. [UNIFESP]
dc.contributor.authorSasso, Gisela R. S. [UNIFESP]
dc.contributor.authorCovarrubias, Charles [UNIFESP]
dc.contributor.authorCortez, Mauro [UNIFESP]
dc.contributor.authorMaeda, Fernando Y. [UNIFESP]
dc.contributor.authorCosta, Fabio Trindade Maranhão [UNIFESP]
dc.contributor.authorYoshida, Nobuko [UNIFESP]
dc.date.accessioned2016-01-24T13:48:52Z
dc.date.available2016-01-24T13:48:52Z
dc.date.issued2007-07-09
dc.identifierhttp://dx.doi.org/10.1186/1475-2875-6-90
dc.identifier.citationMalaria Journal. London: Biomed Central Ltd, v. 6, 6 p., 2007.
dc.identifier.issn1475-2875
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29873
dc.description.abstractObjective: the objective of this study was to investigate whether the infection of C57BL/ 6 mice by P. berghei ANKA, which causes severe malaria, was modulated by co-infection with Trypanosoma cruzi.Methods: Groups of C57BL/ 6 mice were infected either with P. berghei ANKA, T. cruzi strain G, or with both parasites. the presence of parasites was checked by microscopic examination of blood samples. Symptoms of neurological or respiratory disorders, as well as mortality, were registered. Breakdown of the blood brain barrier was determined by injecting the dye Evans blue. Histological sections of the lung were prepared and stained with hematoxilin-eosin.Results: All mice infected only with P. berghei ANKA died within 7-11 days post-infection, either with symptoms of cerebral malaria or with respiratory abnormalities. the animals co- infected with T. cruzi strain G survived longer, without any of the referred to symptoms. Protection against the early death by severe malaria was effective when mice were given T. cruzi 15 days before P. berghei inoculation. Breakdown of the blood brain barrier and extensive pulmonary oedema, caused by malaria parasites, were much less pronounced in co- infected mice. the degree of protection to severe malaria and early death, conferred by co- infection with T. cruzi, was comparable to that conferred by treatment with anti-CD8 antibodies.Conclusion: Co-infection with T. cruzi protects C57BL/ 6 against the early death by malaria infection, by partially preventing either the breakdown of the blood brain, and cerebral malaria as a consequence, or the pulmonary oedema.en
dc.format.extent6
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofMalaria Journal
dc.rightsAcesso aberto
dc.titleCo-infection with Trypanosoma cruzi protects mice against early death by neurological or pulmonary disorders induced by Plasmodium berghei ANKAen
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.description.affiliationUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morfol, São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Parasitol, Campinas, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Morfol, São Paulo, Brazil
dc.identifier.fileWOS000249300000001.pdf
dc.identifier.doi10.1186/1475-2875-6-90
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000249300000001
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