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Title: Central administration of a nitric oxide precursor abolishes both the hypothalamic serotonin release and the hypophagia induced by interleukin-1 beta in obese Zucker rats
Authors: Iuras, Anderson [UNIFESP]
Telles, Monica Marques [UNIFESP]
Bertoncini, Clelia Rejane Antonio [UNIFESP]
Ko, Gui Mi [UNIFESP]
Andrade, Iracema Senna de [UNIFESP]
Silveira, Vera Lucia Flor [UNIFESP]
Ribeiro, Eliane Beraldi [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: Food intake
Brain microdialysis
Ventromedial hypothalamus
Issue Date: 15-Jan-2005
Publisher: Elsevier B.V.
Citation: Regulatory Peptides. Amsterdam: Elsevier B.V., v. 124, n. 1-3, p. 145-150, 2005.
Abstract: Scrotonin-induced anorexia has long been recognized as an important part of the CNS mechanisms controlling energy balance. More recently, interleukin-1beta and nitric oxide have been suggested to influence this control, possibly through modulation of hypothalamic serotonin. the present work aimed at investigating the interaction of these systems. We addressed whether 5-HT is affected during IL-1beta-induced anorexia in obese Zucker rats and the influence of the central NO system on this IL-1beta/5-HT interaction. Using microdialysis, we observed that an intracerebroventricular injection of 10 ng IL-1beta significantly stimulated 5-HT extracellular levels in the VMH, with a peak variation of 102+/-41% above baseline. IL-1beta also significantly reduced the 4-h feeding by 33% and the 24-h feeding by 42%. Contrarily, these effects were absent when IL-1beta was injected 2 h after the i.c.v. administration of 20 mug of the NO precursor L-arginine. the results suggest that, in obese Zucker rats, activation of the serotonergic system in the medial hypothalamus participates in IL-1beta-induced anorexia. Since L-arginine, probably through NO stimulation, abolished both the anorexia and the serotonergic activation, it can be proposed that the NO system, either directly or indirectly, counteracts IL-1beta anorexia. the hypothalamic serotonergic system is likely to mediate this NO effect. (C) 2004 Elsevier B.V. All rights reserved.
ISSN: 0167-0115
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