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Title: Intrauterine undernutrition - renal and vascular origin of hypertension
Authors: Franco, Maria do Carmo Pinho [UNIFESP]
Nigro, D.
Fortes, Z. B.
Tostes, RCA
Carvalho, MHC
Lucas, Sandra Regina Rodrigues [UNIFESP]
Gomes, Guiomar Nascimento [UNIFESP]
Coimbra, Terezila Machado [UNIFESP]
Gil, Frida Zaladek [UNIFESP]
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Keywords: hypertension
renal function
nitric oxide
endothelial function
low birth weight
Issue Date: 1-Nov-2003
Publisher: Elsevier B.V.
Citation: Cardiovascular Research. Amsterdam: Elsevier B.V., v. 60, n. 2, p. 228-234, 2003.
Abstract: A large number of clinical and experimental studies supports the hypothesis that intrauterine undernutrition is an important determinant of hypertension, coronary heart disease and non-insulin-dependent diabetes in the adult offspring. in this review, the renal and vascular repercussions of maternal undernutrition are emphasized, and the physiopatologic mechanisms discussed. the origin of hypertension is detailed based upon the findings of kidney functional parameters and endothelium function studies. A working model linking hypertension to intrauterine undernutrition is proposed. (C) 2003 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
ISSN: 0008-6363
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Appears in Collections:Em verificação - Geral

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