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|Title:||A specific subtype C of human immunodeficiency virus type 1 circulates in Brazil|
|Authors:||Soares, M. A.|
Oliveira, T. de
Brindeiro, R. M.
Diaz, Ricardo Sobhie [UNIFESP]
Sabino, E. C.
Pires, I. L.
Morgado, M. G.
Dantas, M. C.
Teixeira, P. R.
Brazilian Network Drug Reistance S
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Inst Adolfo Lutz Registro
Inst Biol Exercito
Fdn Inst Oswaldo Cruz
drug resistance mutations
HIV in primary infection
|Publisher:||Lippincott Williams & Wilkins|
|Citation:||Aids. Philadelphia: Lippincott Williams & Wilkins, v. 17, n. 1, p. 11-21, 2003.|
|Abstract:||Objective: To characterize the subtype C strains of HIV type I that circulate in Brazil, especially those originated from the southern part of the country.Design and methods: One hundred and twelve HIV-1-positive subjects had their plasma viral RNA extracted. Protease (PR) and reverse transcriptase (RT) genomic regions were polymerase chain reaction-amplified and sequenced for subtype determination. Subtype C strains were selected and compared to other strains of this subtype from the database, and specific amino acid signature patterns were searched.Results: Brazilian subtype C viruses form a very strong monophyletic group when compared to subtype C viruses from other countries and presented specific signature amino acids. Recombinants between subtype C and B viruses have been documented in areas of co-circulation. the incidence of primary PR and RT inhibitor resistance mutations in drug-naive subjects was observed. An increasing number of secondary resistance mutations was also seen, some of which are characteristic of subtype C-related sequences.Conclusions: Introduction of subtype C of HIV-1 in Brazil was likely a single event of one or a mixture of similarly related strains. Recombination between subtype C and B viruses is an ongoing process in the country. Primary and secondary drug resistance mutations were observed, although some of the secondary mutations could be associated with subtype C molecular signatures. Subtype-specific polymorphisms of PR and RT sequences found in this subtype C Brazilian variant might influence this emergence and have an impact on HIV treatment and on vaccine development in the country. (C) 2003 Lippincott Williams Wilkins.|
|Appears in Collections:||Artigo|
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