Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/26413
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dc.contributor.authorSouza, Sandro José de
dc.contributor.authorCamargo, Anamaria A.
dc.contributor.authorBriones, Marcelo Ribeiro da Silva [UNIFESP]
dc.contributor.authorCosta, Fernando Ferreira
dc.contributor.authorNagai, Maria Aparecida
dc.contributor.authorVerjovski-Almeida, Sergio
dc.contributor.authorZago, Marco Antonio
dc.contributor.authorAndrade, Luiz Eduardo Coelho [UNIFESP]
dc.contributor.authorCarrer, Helaine
dc.contributor.authorEl-Dorry, Hamza FA
dc.contributor.authorEspreafico, Enilza M.
dc.contributor.authorHabr-Gama, Angelita
dc.contributor.authorGiannella-Neto, Daniel
dc.contributor.authorGoldman, Gustavo Henrique
dc.contributor.authorGruber, Arthur
dc.contributor.authorHackel, Christine
dc.contributor.authorKimura, Edna Teruko [UNIFESP]
dc.contributor.authorMaciel, Rui Monteiro de Barros [UNIFESP]
dc.contributor.authorMarie, Suely KN
dc.contributor.authorMartins, Elizabeth AL
dc.contributor.authorNobrega, Marina P.
dc.contributor.authorPaçó-Larson, Maria Luisa
dc.contributor.authorPardini, Maria Ines MC
dc.contributor.authorPereira, Gonçalo G.
dc.contributor.authorPesquero, João Bosco [UNIFESP]
dc.contributor.authorRodrigues, Vanderlei
dc.contributor.authorRogatto, Silvia R
dc.contributor.authorSilva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
dc.contributor.authorSogayar, Mari C.
dc.contributor.authorSonati, Maria de Fátima
dc.contributor.authorTajara, Eloisa H.
dc.contributor.authorValentini, Sandro R
dc.contributor.authorAcencio, Marcio
dc.contributor.authorAlberto, Fernando L.
dc.contributor.authorAmaral, Maria Elisabete J
dc.contributor.authorVeiga, Silvio Sanches [UNIFESP]
dc.contributor.authorTravassos, Luiz Rodolpho [UNIFESP]
dc.contributor.authorAneas, Ivy
dc.contributor.authorBengtson, Mario Henrique
dc.contributor.authorCarraro, Dirce Maria
dc.contributor.authorCarvalho, Alex Fiorini de
dc.contributor.authorCarvalho, Lucia Helena
dc.contributor.authorCerutti, Janete Maria [UNIFESP]
dc.contributor.authorCorrea, Maria Lucia C
dc.contributor.authorCosta, Maria Cristina R
dc.contributor.authorCurcio, Cyntia
dc.contributor.authorGushiken, Tsieko
dc.contributor.authorHo, Paulo L.
dc.contributor.authorKimura, Elza
dc.contributor.authorLeite, Luciana CC
dc.contributor.authorMaia, Gustavo
dc.contributor.authorMajumder, Paromita
dc.contributor.authorMarins, Mozart
dc.contributor.authorMatsukuma, Adriana
dc.contributor.authorMelo, Analy Salles de Azevedo [UNIFESP]
dc.contributor.authorMestriner, Carlos Alberto
dc.contributor.authorMiracca, Elisabete C.
dc.contributor.authorMiranda, Daniela C.
dc.contributor.authorNascimento, Ana Lucia Tabet Oller do
dc.contributor.authorNobrega, Francisco G.
dc.contributor.authorOjopi, Elida PB
dc.contributor.authorPandolfi, José Rodrigo C
dc.contributor.authorPessoa, Luciana Gilbert [UNIFESP]
dc.contributor.authorRahal, Paula
dc.contributor.authorRainho, Claudia A.
dc.contributor.authorRo's, Nancy da
dc.contributor.authorSa, Renata G. de
dc.contributor.authorSales, Magaly M.
dc.contributor.authorSilva, Neusa Pereira da [UNIFESP]
dc.contributor.authorSilva, Tereza C.
dc.contributor.authorSilva Junior, Wilson da
dc.contributor.authorSimao, Daniel F.
dc.contributor.authorSousa, Josane F.
dc.contributor.authorStecconi, Daniella
dc.contributor.authorTsukumo, Fernando
dc.contributor.authorValente, Valeria
dc.contributor.authorZalcberg, Heloisa
dc.contributor.authorBrentani, Ricardo Renzo [UNIFESP]
dc.contributor.authorReis, Luiz Fernando Lima
dc.contributor.authorDias-Neto, Emmanuel
dc.contributor.authorSimpson, Andrew JG
dc.date.accessioned2016-01-24T12:31:12Z
dc.date.available2016-01-24T12:31:12Z
dc.date.issued2000-11-07
dc.identifierhttp://dx.doi.org/10.1073/pnas.97.23.12690
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America. Washington: Natl Acad Sciences, v. 97, n. 23, p. 12690-12693, 2000.
dc.identifier.issn0027-8424
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26413
dc.description.abstractTranscribed sequences in the human genome can be identified with confidence only by alignment with sequences derived from cDNAs synthesized from naturally occurring mRNAs. We constructed a set of 250,000 cDNAs that represent partial expressed gene sequences and that are biased toward the central coding regions of the resulting transcripts. They are termed ORF expressed sequence tags (ORESTES). the 250,000 ORESTEs were assembled into 81,429 contigs. of these, 1,181 (1.45%) were found to match sequences in chromosome 22 with at least one ORESTES contig for 162 (65.6%) of the 247 known genes, for 67 (44.6%) of the 150 related genes, and for 45 of the 148 (30.4%) EST-predicted genes on this chromosome. Using a set of stringent criteria to validate our sequences, we identified a further 219 previously unannotated transcribed sequences on chromosome 22. of these, 171 were in fact also defined by EST or full length cDNA sequences available in GenBank but not utilized in the initial annotation of the first human chromosome sequence. Thus despite representing less than 15% of all expressed human sequences in the public databases at the time of the present analysis, ORESTEs sequences defined 48 transcribed sequences on chromosome 22 not defined by other sequences. All of the transcribed sequences defined by ORESTEs coincided with DNA regions predicted as encoding exons by GENSCAN.en
dc.format.extent12690-12693
dc.language.isoeng
dc.publisherNatl Acad Sciences
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of America
dc.rightsAcesso aberto
dc.titleIdentification of human chromosome 22 transcribed sequences with ORF expressed sequence tagsen
dc.typeArtigo
dc.contributor.institutionLudwig Inst Canc Res
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionCtr Biotechnol
dc.contributor.institutionUniv Vale do Paraiba
dc.contributor.institutionUniv Estadual Paulista
dc.description.affiliationLudwig Inst Canc Res, BR-01509010 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Disciplina Reumatol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biofis, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Hemoctr, BR-13089970 Campinas, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Dept Radiol, BR-02196903 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Quim, Dept Bioquim, BR-05513970 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Dept Clin Med, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Dept Morfol, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Dept Parasitol Microbiol & Imunol, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, Escola Super Agr Luiz Queiroz, Dept Ciencias Biol, BR-13418900 Piracicaba, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, INCOR, BR-05403000 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Lab Nutr & Doencas Metab, BR-01246903 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Dept Neurol, BR-01246903 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias Farmaceut, BR-14040903 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Vet & Zootecn, Dept Patol, BR-05508000 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Ciencias Biomed, Dept Histol Embriol, BR-05508000 São Paulo, Brazil
dc.description.affiliationUniv Campinas, Fac Ciencias Med, Dept Med Genet, BR-13081970 Campinas, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, BR-04029032 São Paulo, Brazil
dc.description.affiliationCtr Biotechnol, Inst Butantan, BR-05503900 São Paulo, Brazil
dc.description.affiliationUniv Vale do Paraiba, Inst Pesquisa & Desenvolvimento, BR-12244 Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUniv Campinas, Dept Genet & Evolucao, Inst Biol, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Campinas, Fac Ciencias Med, Dept Patol Clin, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Med Botucatu, Dept Genet, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Med Botucatu, Hemoctr, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationEscola Paulista Med, Dept Obstet & Ginecol, BR-04301900 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Letras & Ciencias Exatas, Inst Biociencias, Dept Biol, BR-05054 Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Disciplina Reumatol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biofis, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, BR-04029032 São Paulo, Brazil
dc.description.affiliationUnifespEscola Paulista Med, Dept Obstet & Ginecol, BR-04301900 São Paulo, Brazil
dc.identifier.doi10.1073/pnas.97.23.12690
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000165225800062
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