Now showing items 1-20 of 35

    • Activation of the Kinin B1 Receptor Attenuates Melanoma Tumor Growth and Metastasis 

      Dillenburg-Pilla, Patricia; Maria, Andrea G.; Reis, Rosana I.; Floriano, Elaine Medeiros; Pereira, Cacilda Dias; De Lucca, Fernando Luiz; Ramos, Simone Gusmao; Pesquero, João Bosco [UNIFESP]; Jasiulionis, Miriam Galvonas [UNIFESP]; Costa-Neto, Claudio M. (Public Library Science, 2013-05-17)
      Melanoma is a very aggressive tumor that does not respond well to standard therapeutic approaches, such as radio-and chemotherapies. Furthermore, acquiring the ability to metastasize in melanoma and many other tumor types ...
    • alpha-L-iduronidase gene-based therapy using the phiC31 system to treat mucopolysaccharidose type I mice 

      Stilhano, Roberta Sessa [UNIFESP]; Martin, Priscila Keiko Matsumoto [UNIFESP]; Melo, Suely Maymone de [UNIFESP]; Samoto, Vivian Yochiko [UNIFESP]; Peres, Giovani Bravin [UNIFESP]; Michelacci, Yara Maria [UNIFESP]; Silva, Flavia Helena da [UNIFESP]; Pereira, Vanessa Gonçalves [UNIFESP]; D'Almeida, Vania [UNIFESP]; Cruz, Adriana Taveira da [UNIFESP]; Jasiulionis, Miriam Galvonas [UNIFESP]; Han, Sang Won [UNIFESP] (Wiley-Blackwell, 2015-01-01)
      BackgroundMucopolysaccharidose type I (MPSI) is a lysosomal monogenic disease caused by mutations in the gene for - l-iduronidase (IDUA). MPSI patients need a constant supply of IDUA to alleviate progression of the disease. ...
    • Angiotensin II Binding to Angiotensin I-Converting Enzyme Triggers Calcium Signaling 

      Guimarães, Paola Bianchi [UNIFESP]; Alvarenga, Erika Costa [UNIFESP]; Siqueira, Paula D. [UNIFESP]; Paredes-Gamero, Edgar Julian [UNIFESP]; Sabatini, Regiane Angelica [UNIFESP]; Morais, Rafael Leite Tavares de [UNIFESP]; Reis, Rosana I.; Santos, Edson L.; Teixeira, Luis Gustavo de Deus [UNIFESP]; Casarini, Dulce Elena [UNIFESP]; Martin, Renan Paulo [UNIFESP]; Shimuta, Suma Imura [UNIFESP]; Carmona, Adriana Karaoglanovic [UNIFESP]; Nakaie, Clovis Ryuichi [UNIFESP]; Jasiulionis, Miriam Galvonas [UNIFESP]; Ferreira, Alice Teixeira [UNIFESP]; Pesquero, Jorge L.; Oliveira, Suzana M. [UNIFESP]; Bader, Michael [UNIFESP]; Costa-Neto, Claudio M.; Pesquero, João Bosco [UNIFESP] (Lippincott Williams & Wilkins, 2011-05-01)
      Angiotensin (Ang) I-converting enzyme (ACE) is involved in the control of blood pressure by catalyzing the conversion of Ang I into the vasoconstrictor Ang II and degrading the vasodilator peptide bradykinin. Human ACE ...
    • Apoptotic Cells Contribute to Melanoma Progression and This Effect is Partially Mediated by the Platelet-Activating Factor Receptor 

      Lacerda Bachi, Andre Luis [UNIFESP]; Santos, Livia Caires dos [UNIFESP]; Nonogaki, Suely; Jancar, Sonia; Jasiulionis, Miriam Galvonas [UNIFESP] (Hindawi Publishing Corporation, 2012-01-01)
      There is evidence that the platelet-activating factor receptor (PAFR) is involved in the clearance of apoptotic cells by macrophages, and that this is associated with anti-inflammatory phenotype. Our group has previously ...
    • Assinaturas moleculares da progressão do melanoma. 

      De Souza, Camila Ferreira [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2013)
      Objetivo: Caracterizar os perfis transcricionais globais das linhagens murinas melan-a, 4C, 4C11- e 4C11+, que representam lesoes melanociticas em estagios fenotipicos distintos. Metodos: A metodologia de microarray foi ...
    • Associação entre Timp1, β1-integrinas e CD63 ao longo da gênese do melanoma 

      Pinto, Mariana Toricelli [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2010-11-24)
      Although malignant melanoma is the less frequently diagnosed skin cancer, it shows a poor prognosis due its chemoresistance and metastasis development. One of the adquired abilities of transformed cells is anoikis resistance ...
    • A cell surface 230 kDa protein from murine melanoma involved with tumor malignancy 

      Mendes, Priscila Fraga Penteado [UNIFESP]; Xander, Patricia [UNIFESP]; Brito, Ronni Romulo Novaes e [UNIFESP]; Mortara, Renato Arruda [UNIFESP]; Jasiulionis, Miriam Galvonas [UNIFESP]; Lopes, Jose Daniel [UNIFESP] (Elsevier B.V., 2008-04-18)
      Because melanoma incidence has increased at a dramatic rate, it is relevant to identify novel melanoma antigens for diagnosis and develop monoclonal antibodies recognizing such molecules. Some monoclonal antibodies (mAbs), ...
    • Componentes da resposta inflamatória aguda que favorecem a progressão do melanoma em modelo murino 

      Bachi, Andre Luis Lacerda [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2009-08-26)
      Chronic inflammation is one of the main factors that predispose to cancer development and contribute to tumor progression. However, some studies show that acute inflammation is also able to generate a microenvironment ...
    • Componentes do ciclo celular ao longo da gênese do melanoma e seus possíveis reguladores 

      Cruz, Adriana Taveira da [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2010-08-25)
      Epigenetic studies regulatory mechanisms of the activity and inheritance in gene expression that is independent of modifications in the nucleotide sequence. The main epigenetic events are: DNA methylation and histone ...
    • Crosstalk between B16 melanoma cells and B-1 lymphocytes induces global changes in tumor cell gene expression 

      Xander, Patricia [UNIFESP]; Novaes e Brito, Ronni Romulo; Perez, Elizabeth Cristina; Pozzibon, Jaqueline Maciel [UNIFESP]; Souza, Camila Ferreira de [UNIFESP]; Pellegrino, Renata [UNIFESP]; Bernardo, Viviane [UNIFESP]; Jasiulionis, Miriam Galvonas [UNIFESP]; Mariano, Mario [UNIFESP]; Lopes, Jose Daniel [UNIFESP] (Elsevier B.V., 2013-10-01)
      The analysis of gene expression patterns in cancers has improved the understanding of the mechanisms underlying the process of metastatic progression. However, the acquisition of invasive behavior in melanoma is poorly ...
    • Endothelial nitric oxide synthase uncoupling as a key mediator of melanocyte malignant transformation associated with sustained stress conditions 

      Melo, Fabiana Henriques Machado de [UNIFESP]; Molognoni, Fernanda [UNIFESP]; Morais, Alice Santana [UNIFESP]; Toricelli, Mariana [UNIFESP]; Mouro, Margaret Gori [UNIFESP]; Higa, Elisa Mieko Suemitsu [UNIFESP]; Lopes, Jose Daniel [UNIFESP]; Jasiulionis, Miriam Galvonas [UNIFESP] (Elsevier B.V., 2011-05-15)
      Melanoma cell lines and cells corresponding to premalignant melanocytes were established by our group after subjecting a nontumorigenic murine melanocyte lineage, melan-a, to sequential cycles of anchorage blockade. Previous ...
    • Epigenetic Modulations in Activated Cells Early after HIV-1 Infection and Their Possible Functional Consequences 

      Maricato, Juliana Terzi [UNIFESP]; Furtado, Maria N. [UNIFESP]; Takenaka, Maisa Carla [UNIFESP]; Nunes, Edsel Renata de Morais [UNIFESP]; Fincatti, Patricia [UNIFESP]; Meliso, Fabiana Marcelino [UNIFESP]; Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]; Jasiulionis, Miriam Galvonas [UNIFESP]; Araripe Sucupira, Maria Cecilia de [UNIFESP]; Diaz, Ricardo Sobhie [UNIFESP]; Janini, Luiz Mário Ramos [UNIFESP] (Public Library Science, 2015-04-13)
      Epigenetic modifications refer to a number of biological processes which alter the structure of chromatin and its transcriptional activity such as DNA methylation and histone post-translational processing. Studies have ...
    • Epigenetic reprogramming as a key contributor to melanocyte malignant transformation 

      Molognoni, Fernanda [UNIFESP]; Cruz, Adriana Taveira da [UNIFESP]; Meliso, Fabiana Marcelino [UNIFESP]; Morais, Alice Santana [UNIFESP]; Souza, Camila Ferreira [UNIFESP]; Xander, Patricia [UNIFESP]; Bischof, Jared M.; Costa, Fabricio F.; Soares, Marcelo B.; Liang, Gangning; Jones, Peter A.; Jasiulionis, Miriam Galvonas [UNIFESP] (Landes Bioscience, 2011-04-01)
      Melanoma progression requires deregulation of gene expression by currently uncharacterized epigenetic mechanisms. A mouse model based on changes in cell microenvironment was developed by our group to study melanocyte ...
    • A expressão de Timp1 associada à desmetilação de seu promotor confere resistência ao anoikis durante a transformação maligna de melanócitos murinos 

      Ricca, Tatiana Iervolino [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2008)
      Embora a resistência ao anoikis seja considerada um importante processo envolvido no fenótipo maligno, a relação causal entre transformação neoplásica e crescimento independente de ancoragem continua indefinida. Para ...
    • FUNCTIONAL HYPOTHESES FOR ABERRANT GLYCOSYLATION IN TUMOR-CELLS 

      Chammas, Roger [UNIFESP]; Jasiulionis, Miriam Galvonas [UNIFESP]; Cury, P. M.; Travassos, Luiz Rodolpho [UNIFESP]; Brentani, Ricardo Renzo [UNIFESP] (Assoc Bras Divulg Cientifica, 1994-02-01)
      Aberrant glycosylation is a common feature of neoplastic cells. Although described for many years, the role of aberrant patterns of glycosylation is not fully understood. Our group has been focusing on the role of glycosylation ...
    • Identificação e caracterização de marcadores relacionados à agressividade do melanoma 

      Monteiro, Ana Carolina [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2019-09-26)
      Melanoma is the most aggressive, treatment-resistant and metastatic skin cancer. It accounts for 80% of all deaths associated with these malignancies. Importantly, tumor vascularization is a critical step of the metastatic ...
    • Instabilidade genômica resultante de alterações teloméricas e centroméricas define a evolução cariotípica do melanoma em um modelo murino 

      Silva, Amanda Goncalves dos Santos [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2009)
      Aneuploidia e instabilidade cromossômica são características da maioria dos tumores sólidos. Estas alterações podem resultar da segregação inapropriada dos cromossomos durante a divisões celulares, que pode ocorrer por ...
    • Laminin-binding proteins in EJ-ras-transformed fibroblasts 

      Chammas, Roger [UNIFESP]; Jasiulionis, Miriam Galvonas [UNIFESP]; Ventura, A. M.; Travassos, Luiz Rodolpho [UNIFESP]; Brentani, Ricardo Renzo [UNIFESP] (Assoc Bras Divulg Cientifica, 1996-09-01)
      Malignant transformation is accompanied by changes in cell-matrix interactions. Upon transfection with EJ-ras oncogene, transformed fibroblasts acquired a migratory phenotype towards laminin-1. The increase in integrin ...
    • Leukotriene B4 Creates a Favorable Microenvironment for Murine Melanoma Growth 

      Bachi, Andre Luis Lacerda [UNIFESP]; Kim, Fabiana Jin Kyung [UNIFESP]; Nonogaki, Suely; Carneiro, Celia Regina Whitaker [UNIFESP]; Lopes, Jose Daniel [UNIFESP]; Jasiulionis, Miriam Galvonas [UNIFESP]; Correa, Mariangela [UNIFESP] (Amer Assoc Cancer Research, 2009-09-01)
      Chronic inflammation has long been associated with neoplastic progression. Our group had recently shown that the addition of a large number of apoptotic tumor cells to the tumor microenvironment induces a potent acute ...