Effects of lithium and valproate on oxidative stress and behavioral changes induced by administration of m-AMPH

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dc.contributor.authorda-Rosa, Dayane D.
dc.contributor.authorValvassori, Samira S.
dc.contributor.authorSteckert, Amanda V.
dc.contributor.authorOrnell, Felipe
dc.contributor.authorFerreira, Camila L.
dc.contributor.authorLopes-Borges, Jessica
dc.contributor.authorVarela, Roger B.
dc.contributor.authorDal-Pizzol, Felipe
dc.contributor.authorAndersen, Monica L. [UNIFESP]
dc.contributor.authorQuevedo, Joao
dc.contributor.institutionUniv So Santa Catarina
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:27:34Z
dc.date.available2016-01-24T14:27:34Z
dc.date.issued2012-08-15
dc.description.abstractIn the last years our research group has studied and validated the animal model of mania induced by dextroamphetamine (D-AMPH). Considering the lack of animal models of mania reported in the literature; this study evaluated the possibilities to validate the animal model induced by methamphetamine (m-AMPH). Then, we evaluated the effects of lithium (Li), valproate (VPA) on the behavior and parameters of oxidative damage in rat brain after administration of m-AMPH. in the prevention treatment, Wistar rats were pretreated with Li. VPA or saline (Sal) for 14 days, and then, between days 8 and 14, rats were treated with m-AMPH (1, 0.5 or 0.25 mg/kg) or Sal. in the reversal treatment, rats were first given m-AMPH (0.25 mg/kg) or Sal. Locomotor behavior was assessed using the open-field task and parameters of oxidative damage were measured in brain structures. Our results show that the hyperactivity was prevented and reverted by Li and VPA only when m-AMPH was administered in the dose of 0.25 mg/kg. in addition, the m-AMPH in all doses administrated induced oxidative damage in both structures tested in two models. Li and VPA reversed and prevented this impairment, however in a way dependent of cerebral area, the dose of m-AMPH and technique. (C) 2012 Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUniv So Santa Catarina, Neurosci Lab, BR-88806000 Criciuma, SC, Brazil
dc.description.affiliationUniv So Santa Catarina, Hlth Sci Unit, Postgrad Program Hlth Sci, Natl Inst Translat Med INCT TM, BR-88806000 Criciuma, SC, Brazil
dc.description.affiliationUniv So Santa Catarina, Lab Expt Pathophysiol, BR-88806000 Criciuma, SC, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent521-526
dc.identifierhttp://dx.doi.org/10.1016/j.psychres.2012.01.019
dc.identifier.citationPsychiatry Research. Clare: Elsevier B.V., v. 198, n. 3, p. 521-526, 2012.
dc.identifier.doi10.1016/j.psychres.2012.01.019
dc.identifier.doidoi.org/10.1016/j.psychres.2012.01.019
dc.identifier.issn0165-1781
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35179
dc.identifier.urihttps://doi.org/10.1016/j.psychres.2012.01.019
dc.identifier.wosWOS:000312044800030
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPsychiatry Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectAnimal model of maniaen
dc.subjectLithiumen
dc.subjectValproateen
dc.subjectMethamphetamineen
dc.subjectOxidative stressen
dc.titleEffects of lithium and valproate on oxidative stress and behavioral changes induced by administration of m-AMPHen
dc.typeinfo:eu-repo/semantics/article
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