Absence epilepsy: Continuum of clinical presentation and epigenetics?

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dc.citation.volume44
dc.contributor.authorGuilhoto, Laura Maria de Figueiredo Ferreira [UNIFESP]
dc.coverageLondon
dc.date.accessioned2020-07-31T12:46:51Z
dc.date.available2020-07-31T12:46:51Z
dc.date.issued2017
dc.description.abstractPurpose: Although absence seizures do predominate in childhood they may occur at all ages and clinical presentation varies widely. Albeit considered a benign seizure type, chronic evolution with therapeutic refractoriness is possible in some patients with absences. The aim of this paper is to summarize the main syndromic presentation of absence seizures and its outcome regarding treatment and prognosis. Method: We performed a review of literature with emphasis in historic and classical manuscripts about absence epilepsy. Results: Absence was described in the beginning of last century as a seizure type with good evolution, but it is still difficult to preview a strict prognosis for an individual patient. Some positive early predictors were reported such as response to initial treatment and seizure onset in childhood. Genetic aspects are not yet well understood although some families have been reported with rare mutations in ion channel coding genes. Conclusion: Absence seizures are present in different epilepsy syndromes and nosological classification is not always possible. Outcome depends on clinical variables such as age of onset, presence of other seizure types and initial response to treatment. (C) 2016 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Sao Paulo, Univ Hosp, Rua Botucatu 740, BR-04023900 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Neurol & Neurosurg, Rua Botucatu 740, BR-04023900 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespDepartment of Neurology and Neurosurgery, Universidade Federal de São Paulo, Rua Botucatu 740, São Paulo, SP, CEP 04023-900, Brazil
dc.description.sourceWeb of Science
dc.format.extent53-57
dc.identifierhttp://dx.doi.org/10.1016/j.seizure.2016.11.031
dc.identifier.citationSeizure-European Journal Of Epilepsy. London, v. 44, p. 53-57, 2017.
dc.identifier.doi10.1016/j.seizure.2016.11.031
dc.identifier.issn1059-1311
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56408
dc.identifier.wosWOS:000394472800011
dc.language.isoeng
dc.publisherW B Saunders Co Ltd
dc.relation.ispartofSeizure-European Journal Of Epilepsy
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAbsence seizureen
dc.subjectGeneralized epilepsyen
dc.subjectTreatmenten
dc.subjectPrognosisen
dc.subjectClassificationen
dc.subjectNosologyen
dc.titleAbsence epilepsy: Continuum of clinical presentation and epigenetics?en
dc.typeinfo:eu-repo/semantics/article
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