Magnesium sulphate given topically by iontophoresis for viability of random skin flaps in rats

dc.contributor.authorYu, Renato Andre
dc.contributor.authorBrumini, Christine
dc.contributor.authorEsteves Junior, Ivaldo
dc.contributor.authorFerreira, Lydia Masako [UNIFESP]
dc.contributor.authorLiebano, Richard Eloin [UNIFESP]
dc.contributor.institutionUniv Estadual Paulista
dc.contributor.institutionUniv Prebiteriana Mackenzie
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv City São Paulo
dc.date.accessioned2016-01-24T13:52:06Z
dc.date.available2016-01-24T13:52:06Z
dc.date.issued2009-01-01
dc.description.abstractOur aim was to assess the effects of magnesium sulphate given by iontophoresis on the viability of random skin flaps in rats. Endovenous magnesium sulphate is used to treat pre-eclampsia and diseases of blood vessels. Iontophoresis is an electrotherapeutic method which has shown satisfactory results in controlling ischaemia within the boundaries of the area in which it was given. Forty-five adult male Wistar rats, weighing 300 to 440 g were randomly divided into three groups of 15 animals each: random skin flap (control); random skin flap treated with magnesium sulphate without electrical stimulation; and random skin flap treated with magnesium sulphate with electrical stimulation of 4 mA for 20 minutes. the treatments were applied immediately after the operation and repeated on the following two days. the percentage of necrotic area was measured on the seventh postoperative day using a paper template. for each group, the mean percentage of flap necrosis was as follows: control, 46%; magnesium sulphate without electrical stimulation, 34%; and magnesium sulphate with electrical stimulation, 42%. There was no significant difference among the groups (p=0.18). Magnesium sulphate given by iontophoresis does not increase the viability of random skin flaps in rats.en
dc.description.affiliationUniv Estadual Paulista, Phys Therapy Dept, São Paulo, Brazil
dc.description.affiliationUniv Prebiteriana Mackenzie, Phys Therapy Dept, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Div Plast Surg, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Surg, São Paulo, Brazil
dc.description.affiliationUniv City São Paulo, Phys Therapy Dept, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Plast Surg, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Surg, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent197-200
dc.identifierhttp://dx.doi.org/10.1080/02844310902840122
dc.identifier.citationScandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery. Oslo: Taylor & Francis As, v. 43, n. 4, p. 197-200, 2009.
dc.identifier.doi10.1080/02844310902840122
dc.identifier.issn0284-4311
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31190
dc.identifier.wosWOS:000269068100002
dc.language.isoeng
dc.publisherTaylor & Francis As
dc.relation.ispartofScandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
dc.rightsAcesso restrito
dc.rights.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.subjectSurgical flapsen
dc.subjectischemiaen
dc.subjectmagnesium sulphateen
dc.subjectiontophoresisen
dc.titleMagnesium sulphate given topically by iontophoresis for viability of random skin flaps in ratsen
dc.typeArtigo
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