En Face Doppler Optical Coherence Tomography Measurement of Total Retinal Blood Flow in Diabetic Retinopathy and Diabetic Macular Edema

Página do item simplificado
dc.citation.issue3
dc.citation.volume135
dc.contributor.authorLee, ByungKun
dc.contributor.authorNovais, Eduardo A. [UNIFESP]
dc.contributor.authorWaheed, Nadia K.
dc.contributor.authorAdhi, Mehreen
dc.contributor.authorde Carlo, Talisa E.
dc.contributor.authorCole, Emily D.
dc.contributor.authorMoult, Eric M.
dc.contributor.authorChoi, WooJhon
dc.contributor.authorLane, Mark
dc.contributor.authorBaumal, Caroline R.
dc.contributor.authorDuker, Jay S.
dc.contributor.authorFujimoto, James G.
dc.coverageChicago
dc.date.accessioned2020-07-17T14:02:47Z
dc.date.available2020-07-17T14:02:47Z
dc.date.issued2017
dc.description.abstractIMPORTANCE Alterations in ocular blood flow play an important role in the pathogenesis and progression of diabetic retinopathy (DR). However, the measurement of retinal blood flow in clinical studies has been challenging. En face Doppler optical coherence tomography (OCT) provides an effectivemethod for measuring total retinal blood flow (TRBF) in the clinic. OBJECTIVE To investigate TRBF in eyes with DR of varying severity, with or without diabetic macular edema (DME), using en face Doppler OCT. DESIGN, SETTING, AND PARTICIPANTS Thiswas a cross-sectional study conducted from May 23, 2014, to January 11, 2016, which analyzed 41 eyes with DR from 31 diabetic patients, 20 eyes without DR from 11 diabetic patients, and 16 eyes from 12 healthy age-matched controls, all at the New England Eye Center in Boston, Massachusetts. MAIN OUTCOMES AND MEASURES Participantswere imaged with a high-speed, swept-source OCT prototype at 1050-nm wavelength using repeated en face Doppler OCT raster scans, comprising 600 x 80 axial scans and covering a 1.5 x 2-mm(2) area centered at the optic disc. The TRBF was automatically calculated using custom Matlab software. RESULTS This study included 41 eyes with DR from 31 diabetic patients (mean [SD] age, 62.8 [13.4] yearsen
dc.description.abstract12 were female patients), 20 eyes without DR from 11 diabetic patients (mean [SD] age, 58.8 [10.1] yearsen
dc.description.abstract5 were female patients), and 16 eyes from 12 healthy age-matched controls (mean [SD] age, 57.9 [8.1] yearsen
dc.description.abstract8 were female participants). The mean (SD) TRBF was 28.0 (8.5) mu L/min in the eyes with DME, 48.8 (13.4) mu L/min in the eyes with DR but without DME, 40.1 (7.7) mu L/min in the diabetic eyes without retinopathy, and 44.4 (8.3) mu L/min in age-matched healthy eyes. A difference in TRBF between the eyes with DME that were treated and the eyes with DME that were not treated was not identified. The TRBF was consistently low in the eyes with DME regardless of DR severity. The eyes with moderate nonproliferative DR but without DME exhibited a wide range of TRBF from 31.1 to 75.0 mu L/min, with the distribution being highly skewed. CONCLUSIONS AND RELEVANCE High-speed en face Doppler OCT can measure TRBF in healthy and diabetic eyes. Diabetic eyes with DME exhibited lower TRBF than healthy eyes (P <= .001). Further longitudinal studies of TRBF in eyes with DR would be helpful to determine whether reduced TRBF is a risk factor for DME.en
dc.description.affiliationMIT, Dept Elect Engn & Comp Sci, 77 Massachusetts Ave,Room 36-361, Cambridge, MA 02142 USA
dc.description.affiliationMIT, Elect Res Lab, Cambridge, MA 02139 USA
dc.description.affiliationTufts Med Ctr, New England Eye Ctr, Boston, MA USA
dc.description.affiliationUniv Fed Sao Paulo, Sch Med, Sao Paulo, Brazil
dc.description.affiliationUniv Hosp Birmingham NHS Fdn Trust, Queen Elizabeth Hosp Birmingham, Birmingham, England
dc.description.affiliationUnifespUniv Fed Sao Paulo, Sch Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Institute of Health
dc.description.sponsorshipAir Force Office of Scientific Research
dc.description.sponsorshipMacula Vision Research Foundation
dc.description.sponsorshipChampalimaud Foundation
dc.description.sponsorshipMassachusetts Lions Club
dc.description.sponsorshipSamsung Scholarship from Seoul, South Korea
dc.description.sponsorshipCoordination for the Improvement of Higher Education Personnel Foundation within the Ministry of Education of Brazil, Brasilia, Distrito Federal, Brazil
dc.description.sponsorshipIDNational Institute of Health: R01-EY011289-30
dc.description.sponsorshipIDNational Institute of Health: R44-EY022864-03
dc.description.sponsorshipIDNational Institute of Health: R0-1CA075289-19
dc.description.sponsorshipIDAir Force Office of Scientific Research: FA-9550-15-1-0473
dc.description.sponsorshipIDAir Force Office of Scientific Research: FA9550-12-1-0499
dc.format.extent244-251
dc.identifierhttp://dx.doi.org/10.1001/jamaophthalmol.2016.5774
dc.identifier.citationJama Ophthalmology. Chicago, v. 135, n. 3, p. 244-251, 2017.
dc.identifier.doi10.1001/jamaophthalmol.2016.5774
dc.identifier.issn2168-6165
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55013
dc.identifier.wosWOS:000397493800018
dc.language.isoeng
dc.publisherAmer Medical Assoc
dc.relation.ispartofJama Ophthalmology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleEn Face Doppler Optical Coherence Tomography Measurement of Total Retinal Blood Flow in Diabetic Retinopathy and Diabetic Macular Edemaen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos