Efeito da leucina na hipertrofia cardíaca e na concentração sérica de creatina quinase em ratos Wistar em hipertireoidismo experimental

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dc.contributor.authorFidale, Thiago Montes
dc.contributor.authorGoncalves, Alexandre
dc.contributor.authorParanhos Lopes, Leandro Teixeira
dc.contributor.authorAlves, Poliana Rodrigues
dc.contributor.authorSouza, Fernanda Rodrigues de
dc.contributor.authorDias Nunes, Joao Elias
dc.contributor.authorMundim, Antonio Vicente
dc.contributor.authorResende, Elmiro Santos [UNIFESP]
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.contributor.institutionUniversidade de Brasília (UnB)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T14:04:27Z
dc.date.available2018-06-15T14:04:27Z
dc.date.issued2013-03-01
dc.description.abstractLeucine is a regulator of protein metabolism in vivo, and there is little information regarding its action on cardiac hypertrophy induced by experimental hyperthyroidism and its relationship to serum creatine kinase. The study aimed to verify the effect of leucine in cardiac hypertrophy and serum creatine kinase in rats with hyperthyroidism. We used 20 animals were divided into four groups and these control, hormone, hormone + leucine and leucine. Hyperthyroidism was induced by administration of daily 20 mu g/100 grams of levothyroxine sodium in aqueous suspension by gavage. Leucine was supplemented by adding 5% of the amino conventional diet. Blood was collected by cardiac puncture and analyzes made in kit CK-NAC, CK-MB and TSH. At the end of the trial period of seven days the hearts were removed and weighed. Subsequently, the left ventricle was separated together with the interventricular septum and weighed. In statistical comparison was used analysis of variance (ANOVA) and two-way post-Tukey test, considering p values <0.05. Serum concentrations of serum CK-MB were lower in leucine (p <0.05) and hormone + leucine (p <0.05) compared to control. The hormone group, showed greater relative heart weight than the control group (p <0.05) and absolute heart weight greater than hormone + leucine (p <0.05). In conclusion, leucine appears to reduce cardiac hypertrophy and serum concentration of creatine kinase by unknown mechanisms.en
dc.description.affiliationUniv Fed Uberlandia, PGCS, Uberlandia, MG, Brazil
dc.description.affiliationUniv Brasilia, Brasilia, DF, Brazil
dc.description.affiliationUniv Fed Uberlandia, Fac Educ Fis FAEFI, Uberlandia, MG, Brazil
dc.description.affiliationUniv Fed Uberlandia, Fac Med Vet FAMEV, Uberlandia, MG, Brazil
dc.description.affiliationUNIFESP, Uberlandia, MG, Brazil
dc.description.affiliationUniv Fed Uberlandia, Fac Med FAMED, Uberlandia, MG, Brazil
dc.description.affiliationUnifespUNIFESP, Uberlandia, MG, Brazil
dc.description.sourceWeb of Science
dc.format.extent499-505
dc.identifierhttp://www.seer.ufu.br/index.php/biosciencejournal/article/view/17649/12302
dc.identifier.citationBioscience Journal. Uberlandia: Univ Federal Uberlandia, v. 29, n. 2, p. 499-505, 2013.
dc.identifier.fileWOS000318222800027.pdf
dc.identifier.issn1516-3725
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/42840
dc.identifier.wosWOS:000318222800027
dc.language.isopor
dc.publisherUniv Federal Uberlandia
dc.relation.ispartofBioscience Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCreatine kinaseen
dc.subjectHyperthyroidismen
dc.subjectLeucineen
dc.subjectInfarctionen
dc.subjectWistaren
dc.titleEfeito da leucina na hipertrofia cardíaca e na concentração sérica de creatina quinase em ratos Wistar em hipertireoidismo experimentalpt
dc.title.alternativeEffect of leucine in cardiac hypertrophy and serum creatine kinase in rats in experimental hyperthyroidismen
dc.typeinfo:eu-repo/semantics/article
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