Effect of thyroparathyroidectomy on urinary acidification in diabetic rats

dc.contributor.authorGil, Frida Zaladek [UNIFESP]
dc.contributor.authorCavanal, Maria de Fátima [UNIFESP]
dc.contributor.authorNascimento-Gomes, G. [UNIFESP]
dc.contributor.authorSilva-Rocha, M.c. [UNIFESP]
dc.contributor.authorNutti-de-Almeida, M. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:24:49Z
dc.date.available2015-06-14T13:24:49Z
dc.date.issued1999-01-01
dc.description.abstractIn previous studies we have shown stimulation of renal acid excretion in the proximal tubules of rats with diabetes of short duration, with no important alterations in glomerular hemodynamics; on the other hand, in thyroparathyroidectomized rats (TPTX model), a significant decrease in renal acid excretion, glomerular filtration rate (GFR) and renal plasma flow (RPF) was detected. Since important changes in the parathyroid hormone-vitamin D-Ca axis are observed in the diabetic state, the present study was undertaken to investigate the renal repercussions of thyroparathyroidectomy in rats previously made diabetic by streptozotocin (45 mg/kg). Four to 6 days after the induction of diabetes (DM), a group of rats were thyroparathyroidectomized (DM + TPTX). Renal functional parameters were evaluated by measuring the inulin and sodium para-aminohippurate clearance on the tenth day. The decrease in the GFR and RPF observed in TPTX was not reversed by diabetes since the same alterations were observed in DM + TPTX. Net acid (NA) excretion was unchanged in DM (6.19 ± 0.54), decreased in TPTX (3.76 ± 0.25) and returned to normal levels in DM + TPTX (5.54 ± 0.72) when compared to the control group (6.34 ± 0.14 µmol min-1 kg-1). The results suggest that PTH plays an important vasodilator role regarding glomerular hemodynamics, since in its absence the impairment in GFR and RPF was not reversed by the diabetic state. However, with respect to acid excretion, the presence of diabetes was able to overcome the negative stimulus represented by TPTX.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUnifespUNIFESP
dc.description.sourceSciELO
dc.format.extent107-113
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X1999000100016
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 1, p. 107-113, 1999.
dc.identifier.doi10.1590/S0100-879X1999000100016
dc.identifier.fileS0100-879X1999000100016.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X1999000100016
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/728
dc.identifier.wosWOS:000078324100016
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsAcesso aberto
dc.subjectdiabetesen
dc.subjectthyroparathyroidectomyen
dc.subjectrenal functionen
dc.subjectacid excretionen
dc.titleEffect of thyroparathyroidectomy on urinary acidification in diabetic ratsen
dc.typeArtigo
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