Abnormal Brain Connectivity Patterns in Adults with ADHD: A Coherence Study

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dc.contributor.authorSato, Joao Ricardo [UNIFESP]
dc.contributor.authorHoexter, Marcelo Queiroz [UNIFESP]
dc.contributor.authorCastellanos, Xavier Francisco
dc.contributor.authorRohde, Luis A.
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Clin Porto Alegre
dc.contributor.institutionNYU
dc.contributor.institutionInst Nacl Psiquiatria Desenvolvimento
dc.date.accessioned2016-01-24T14:27:43Z
dc.date.available2016-01-24T14:27:43Z
dc.date.issued2012-09-26
dc.description.abstractStudies based on functional magnetic resonance imaging (fMRI) during the resting state have shown decreased functional connectivity between the dorsal anterior cingulate cortex (dACC) and regions of the Default Mode Network (DMN) in adult patients with Attention-Deficit/Hyperactivity Disorder (ADHD) relative to subjects with typical development (TD). Most studies used Pearson correlation coefficients among the BOLD signals from different brain regions to quantify functional connectivity. Since the Pearson correlation analysis only provides a limited description of functional connectivity, we investigated functional connectivity between the dACC and the posterior cingulate cortex (PCC) in three groups (adult patients with ADHD, n = 21; TD age-matched subjects, n = 21; young TD subjects, n = 21) using a more comprehensive analytical approach - unsupervised machine learning using a one-class support vector machine (OC-SVM) that quantifies an abnormality index for each individual. the median abnormality index for patients with ADHD was greater than for TD age-matched subjects (p = 0.014); the ADHD and young TD indices did not differ significantly (p = 0.480); the median abnormality index of young TD was greater than that of TD age-matched subjects (p = 0.016). Low frequencies below 0.05 Hz and around 0.20 Hz were the most relevant for discriminating between ADHD patients and TD age-matched controls and between the older and younger TD subjects. in addition, we validated our approach using the fMRI data of children publicly released by the ADHD-200 Competition, obtaining similar results. Our findings suggest that the abnormal coherence patterns observed in patients with ADHD in this study resemble the patterns observed in young typically developing subjects, which reinforces the hypothesis that ADHD is associated with brain maturation deficits.en
dc.description.affiliationUniv Fed ABC, Ctr Math Computat & Cognit, Santo Andre, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Lab Interdisciplinar Neurociencias Clin, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationHosp Clin Porto Alegre, Child & Adolescent Psychiat Div, ADHD Outpatient Program, Porto Alegre, RS, Brazil
dc.description.affiliationNYU, Ctr Child Study, Phyllis Green & Randolph Cowen Inst Pediat Neuros, New York, NY USA
dc.description.affiliationInst Nacl Psiquiatria Desenvolvimento, Porto Alegre, RS, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Lab Interdisciplinar Neurociencias Clin, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipNational Institute of Mental Health
dc.description.sponsorshipNovartis
dc.description.sponsorshipJanssen-Cilag
dc.description.sponsorshipAbbott
dc.description.sponsorshipEli-Lilly
dc.description.sponsorshipShire
dc.description.sponsorshipBristol-Myers Squibb
dc.description.sponsorshipIDNational Institute of Mental Health: R01MH083246
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0045671
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 7, n. 9, 9 p., 2012.
dc.identifier.doi10.1371/journal.pone.0045671
dc.identifier.fileWOS000309517300042.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35284
dc.identifier.wosWOS:000309517300042
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleAbnormal Brain Connectivity Patterns in Adults with ADHD: A Coherence Studyen
dc.typeinfo:eu-repo/semantics/article
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