Inflammatory cytokines as an underlying mechanism of the comorbidity between bipolar disorder and migraine

dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.contributor.authorMansur, Rodrigo B. [UNIFESP]
dc.contributor.authorGrassi-Oliveira, Rodrigo
dc.contributor.authorSoczynska, Joanna K.
dc.contributor.authorMcIntyre, Roger S.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionPontificia Univ Catolica Rio Grande do Sul
dc.contributor.institutionUniv Hlth Network
dc.contributor.institutionUniv Toronto
dc.date.accessioned2016-01-24T14:27:12Z
dc.date.available2016-01-24T14:27:12Z
dc.date.issued2012-05-01
dc.description.abstractA bi-directional association between mood disorders and migraine has been consistently reported. Nevertheless, the neurobiological substrate underlying the association between these disorders remains unknown. in the article herein we review evidence for the role of inflammatory cytokines in the neurobiology of bipolar disorder and migraine. in addition, inflammation is hypothesized to be a shared pathophysiological mechanism subserving the bipolar disorder and migraine concomitance. A derivative of this hypothesis is that pharmacological treatments primarily targeting the inflammatory system may have symptom suppressing effects in bipolar disorder. (c) 2012 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, Program Recognit & Intervent Individuals Risk Men, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LINC, São Paulo, Brazil
dc.description.affiliationPontificia Univ Catolica Rio Grande do Sul, Postgrad Program Psychol, Dev Cognit Neurosci Res Grp, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada
dc.description.affiliationUniv Toronto, Inst Med Sci, Toronto, ON M5S 1A1, Canada
dc.description.affiliationUniv Toronto, Dept Pharmacol & Psychiat, Toronto, ON, Canada
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, Program Recognit & Intervent Individuals Risk Men, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LINC, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent601-605
dc.identifierhttp://dx.doi.org/10.1016/j.mehy.2012.01.036
dc.identifier.citationMedical Hypotheses. Edinburgh: Churchill Livingstone, v. 78, n. 5, p. 601-605, 2012.
dc.identifier.doi10.1016/j.mehy.2012.01.036
dc.identifier.issn0306-9877
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34861
dc.identifier.wosWOS:000303271900007
dc.language.isoeng
dc.publisherChurchill Livingstone
dc.relation.ispartofMedical Hypotheses
dc.rightsAcesso restrito
dc.titleInflammatory cytokines as an underlying mechanism of the comorbidity between bipolar disorder and migraineen
dc.typeArtigo
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