Casein kinase I epsilon (CKI epsilon) N408 allele is very rare in the Brazilian population and is not involved in susceptibility to circadian rhythm sleep disorders

dc.contributor.authorCastro, Rosa M. R. P. S. [UNIFESP]
dc.contributor.authorBarbosa, Ana A. [UNIFESP]
dc.contributor.authorPedrazzoli, Mario [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:51:53Z
dc.date.available2016-01-24T13:51:53Z
dc.date.issued2008-11-03
dc.description.abstractCircadian rhythms are regulated by clock proteins through post-translational modifications. Indeed, Casein kinase I epsilon (CKI epsilon) promotes reversible phosphorylation of PER proteins, and a deficiency in this phosphorylation has been implicated in human sleep disorders. Here, we investigated the CKI epsilon S408N polymorphism in a Brazilian population sample. the N408 allele was previously described to be much less frequent in individuals with Delayed Sleep-Phase Syndrome (DSPS), than in the general Japanese population, Suggesting a protective function for the allele against the disease. We found that this polymorphism is very rare in the Brazilian population (1.37%), indicating that it has no influence on susceptibility to circadian rhythm sleep disorders. Therefore, it is necessary to account for adaptative influences in genetic background, analyzing different groups with different photoperiods, to validate the effects of this and other polymorphisms on sleep and circadian disorders. (C) 2008 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, Dept Psychobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAFIP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCEPID
dc.description.sponsorshipIDFAPESP: 06/58104-2
dc.description.sponsorshipIDCEPID: 98/143003-3
dc.format.extent156-157
dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2008.05.005
dc.identifier.citationBehavioural Brain Research. Amsterdam: Elsevier B.V., v. 193, n. 1, p. 156-157, 2008.
dc.identifier.doi10.1016/j.bbr.2008.05.005
dc.identifier.issn0166-4328
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31031
dc.identifier.wosWOS:000258738400021
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBehavioural Brain Research
dc.rightsAcesso restrito
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectcircadian rhythmsen
dc.subjectsleep disordersen
dc.subjectcasein kinase I epsilonen
dc.subjectdelayed sleep-phase syndromeen
dc.subjectpolymorphismsen
dc.titleCasein kinase I epsilon (CKI epsilon) N408 allele is very rare in the Brazilian population and is not involved in susceptibility to circadian rhythm sleep disordersen
dc.typeArtigo
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