Nevus-Associated Melanomas: Clinicopathologic Features

dc.contributor.authorShitara, Danielle [UNIFESP]
dc.contributor.authorNascimento, Mauricio M. [UNIFESP]
dc.contributor.authorPuig, Susana
dc.contributor.authorYamada, Sergio [UNIFESP]
dc.contributor.authorEnokihara, Milvia M. S. S. [UNIFESP]
dc.contributor.authorMichalany, Nilceo [UNIFESP]
dc.contributor.authorBagatin, Edileia [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Barcelona
dc.contributor.institutionInst Salud Carlos III
dc.date.accessioned2016-01-24T14:37:54Z
dc.date.available2016-01-24T14:37:54Z
dc.date.issued2014-10-01
dc.description.abstractObjectives: the clinical significance of nevus-associated melanoma compared with de novo melanomas remains controversial. It has been suggested that nevus-associated melanomas have a higher Breslow thickness and therefore worse prognosis. Over a 10-year period, this study evaluated the incidence of nevus-associated melanoma and its prognostic significance related to clinicopathologic features.Methods: Cross-sectional study from 1995 through 2004 in a dermatopathology referral center. With available data, we evaluated sex, primary location, histologic subtype, Breslow thickness, Clark level, presence of ulceration, associated lesion, and histologic subtype of the associated lesion.Results: of 135,653 pathologic records from skin biopsy specimens over a 10-year period, 1,190 melanoma records were selected Nevus-associated melanomas corresponded to 390 (32.8%) melanomas, with thin melanomas having a nevus 1.52 times the association observed with thick melanomas (>1.01 mm; 95% confidence interval, 1.16-1.99; P <.001). Superficial spreading melanoma was the most frequent, while no lentigo maligna melanoma was associated with nevi. the median Breslow thickness of nevus-associated melanomas was lower than that of de novo melanomas.Conclusions: Nevus-associated melanomas, which represent one-third of the melanomas in southeast Brazil, are associated with intermittent sun exposure, superficial spreading melanomas, and lower Breslow thickness. This is one of the largest series describing nevus-associated melanomas in Latin America.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Dermatol, BR-04038001 São Paulo, Brazil
dc.description.affiliationUniv Barcelona, Dept Dermatol, Hosp Clin Barcelona, Melanoma Unit,IDIBAPS, Barcelona, Spain
dc.description.affiliationInst Salud Carlos III, CIBER Enfermedades Raras, Barcelona, Spain
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, BR-04038001 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Dermatol, BR-04038001 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, BR-04038001 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2012-15238-0
dc.format.extent485-491
dc.identifierhttp://dx.doi.org/10.1309/AJCP4L5CJGKTJVDD
dc.identifier.citationAmerican Journal of Clinical Pathology. Chicago: Amer Soc Clinical Pathology, v. 142, n. 4, p. 485-491, 2014.
dc.identifier.doi10.1309/AJCP4L5CJGKTJVDD
dc.identifier.issn0002-9173
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38252
dc.identifier.wosWOS:000342409600011
dc.language.isoeng
dc.publisherAmer Soc Clinical Pathology
dc.relation.ispartofAmerican Journal of Clinical Pathology
dc.rightsAcesso aberto
dc.subjectNevus-associated melanomasen
dc.subjectDe novo melanomaen
dc.subjectBreslowen
dc.subjectHistologic subtypeen
dc.titleNevus-Associated Melanomas: Clinicopathologic Featuresen
dc.typeArtigo
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