Prevalence of chronic kidney disease and comorbidities in isolated African descent communities (PREVRENAL): methodological design of a cohort study

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dc.citation.volume19
dc.contributor.authorSalgado-Filho, Natalino
dc.contributor.authorLages, Joyce Santos
dc.contributor.authorBrito, Dyego Jose
dc.contributor.authorSalgado, Joao Victor
dc.contributor.authorSilva, Gyl Eanes
dc.contributor.authorSantos, Alcione Miranda
dc.contributor.authorMonteiro-Junior, Francisco Chagas
dc.contributor.authorSantos, Elisangela Milhomen
dc.contributor.authorSilva, Antonio Augusto
dc.contributor.authorAraujo, Denizar Vianna
dc.contributor.authorSesso, Ricardo Castro [UNIFESP]
dc.coverageLondon
dc.date.accessioned2020-07-08T13:09:38Z
dc.date.available2020-07-08T13:09:38Z
dc.date.issued2018
dc.description.abstractBackground: Chronic kidney disease (CKD) is considered a serious public health problem, both in Brazil and worldwide, with an increasing number of cases observed inrecent years. Especially, CKD has been reported to be highly prevalent in those of African descent. However, Brazil lacks data from early-stage CKD population studies, and the prevalence of CKD is unknown for both the overall and African descent populations. Hence, the present study aims to estimate the prevalence of early-stage CKD and its associated risk factors in African-Brazilians from isolated African-descent communities. Herein, the detailed methodology design of the study is described. Methods: This population-based, prospective, longitudinal, cohort study (PREVRENAL) is performed in three stages: first, clinical, nutritional, and anthropometric evaluationsen
dc.description.abstractmeasurements of serum and urinary markersen
dc.description.abstractand examinations of comorbidities were performed. Second, repeated examinations of individuals with CKD, systemic arterial hypertension, and/or diabetes mellitusen
dc.description.abstractimage screeningen
dc.description.abstractand cardiac risk assessment were performed. Third, long-term monitoring of all selected individuals will be conducted (ongoing). Using probability sampling, 1539 individuals from 32 communities were selected. CKD was defined asaglomerular filtration rate (GFR) <= 60 mL/min/1.73m(2) and albuminuria > 30 mg/day. Discussion: This study proposes to identify and monitor individuals with and without reduced GFR and high albuminuria in isolated populations of African descendants in Brazil. As there are currently no specific recommendations for detecting CKD in African descendants, four equations for estimating the GFR based on serum creatinine and cystatin C were used and will be retrospectively compared. The present report describes the characteristics of the target population, selection of individuals, and detection of a population at risk, along with the imaging, clinical, and laboratory methodologies used. The first and second stages have been concluded and the results will be published in the near future. The subsequent (third) stage is the long-term, continuous monitoring of individuals diagnosed with renal abnormalities or with CKD risk factors. The entire study population will be re-evaluated five years after the study initiation. The expectation is to obtain information about CKD evolution among this population, including the progression rate, complication development, and cardiovascular events.en
dc.description.affiliationUniv Fed Maranhao, Kidney Dis Prevent Ctr, Sao Luis, MA, Brazil
dc.description.affiliationUniv Fed Maranhao, Dept Med 1, Sao Luis, MA, Brazil
dc.description.affiliationUniv Fed Maranhao, Dept Publ Hlth, Sao Luis, MA, Brazil
dc.description.affiliationUniv Fed Maranhao, Kidney Dis Prevent Ctr, Sao Luis, MA, Brazil
dc.description.affiliationUniv Fed Maranhao, Dept Physiol Sci, Sao Luis, MA, Brazil
dc.description.affiliationUniv Sao Paulo, Ribeirao Preto Sch Med, Dept Pathol & Radiol, Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Estado Rio De Janeiro, Dept Internal Med, Rio De Janeiro, RJ, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Paulista Sch Med, Discipline Nephrol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Paulista Sch Med, Discipline Nephrol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipResearch Support Foundation of Maranhao (Fundacao de Amparo a Pesquisa do Maranhao - FAPEMA)
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1186/s12882-018-0839-z
dc.identifier.citationBmc Nephrology. London, v. 19, p. -, 2018.
dc.identifier.doi10.1186/s12882-018-0839-z
dc.identifier.fileWOS000426085300002.pdf
dc.identifier.issn1471-2369
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54109
dc.identifier.wosWOS:000426085300002
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofBmc Nephrology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAfricanen
dc.subjectKidney diseaseen
dc.subjectGlomerular filtration rateen
dc.subjectBrazilen
dc.subjectPopulation studyen
dc.titlePrevalence of chronic kidney disease and comorbidities in isolated African descent communities (PREVRENAL): methodological design of a cohort studyen
dc.typeinfo:eu-repo/semantics/article
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