Acai (euterpe oleracea mart.) Upregulates paraoxonase 1 gene expression and activity with concomitant reduction of hepatic steatosis in high-fat diet-fed rats

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dc.contributor.authorPereira, Renata Rebeca
dc.contributor.authorMallosto Emerich de Abreu, Isabel Cristina [UNIFESP]
dc.contributor.authorda Costa Guerra, Joyce Ferreira
dc.contributor.authorLage, Nara Nunes
dc.contributor.authorMacedo Lopes, Juliana Marcia
dc.contributor.authorSilva, Maisa
dc.contributor.authorde Lima, Wanderson Geraldo
dc.contributor.authorSilva, Marcelo Eustaquio
dc.contributor.authorPedrosa, Maria Lucia
dc.date.accessioned2019-01-21T10:29:50Z
dc.date.available2019-01-21T10:29:50Z
dc.date.issued2016
dc.description.abstractAcai (Euterpe oleracea Mart.), a fruit from the Amazon region, has emerged as a promising source of polyphenols. Acai consumption has been increasing owing to ascribed health benefits and antioxidant propertiesen
dc.description.abstracthowever, its effects on hepatic injury are limited. In this study, we evaluated the antioxidant effect of filtered acai pulp on the expression of paraoxonase (PON) isoforms and PON1 activity in rats with nonalcoholic fatty liver disease (NAFLD). The rats were fed a standard AIN-93M (control) diet or a high-fat (HF) diet containing 25% soy oil and 1% cholesterol with or without acai pulp (2 g/day) for 6 weeks. Our results show that acai pulp prevented low-density lipoprotein (LDL) oxidation, increased serum and hepatic PON1 activity, and upregulated the expression of PON1 and ApoA-I in the liver. In HF diet-fed rats, treatment with acai pulp attenuated liver damage, reducing fat infiltration and triglyceride (TG) content. In rats receiving acai, increased serum PON1 activity was correlated with a reduction in hepatic steatosis and hepatic injury. These findings suggest the use of acai as a potential therapy for liver injuries, supporting the idea that dietary antioxidants are a promising approach to enhance the defensive systems against oxidative stress.en
dc.description.affiliationResearch Center in Biological Sciences, Federal University of Ouro Preto, 35400-000 Ouro Preto, MG, Brazil
dc.description.affiliationDepartment of Biological Sciences, Federal University of Ouro Preto, 35400-000 Ouro Preto, MG, Brazil
dc.description.affiliationFederal University of São Paulo, 04039-002 São Paulo, SP, Brazil
dc.description.affiliationPostgraduate Program in Health and Nutrition, Federal University of Ouro Preto, 35400-000 Ouro Preto, MG, Brazil
dc.description.affiliationDepartment of Basic Health, Federal University of Juiz de Fora, Governador Valadares Campus, 35010-177 Governador Valadares, MG, Brazil
dc.description.affiliationDepartment of Foods, Federal University of Ouro Preto, 35400-000 Ouro Preto, MG, Brazil
dc.description.affiliationUnifespFederal University of São Paulo, 04039-002 São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFAPEMIG Foundation (Research Support Foundation of Minas Gerais State)
dc.description.sponsorshipCNPq (National Council for Scientific and Technological Development)
dc.description.sponsorshipFederal University of Ouro Preto, Ouro Preto, MG, Brazil
dc.identifierhttp://dx.doi.org/10.1155/2016/8379105
dc.identifier.citationOxidative Medicine And Cellular Longevity. London, 2016.
dc.identifier.doi10.1155/2016/8379105
dc.identifier.fileWOS000382640100001.pdf
dc.identifier.issn1942-0900
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49425
dc.identifier.wosWOS:000382640100001
dc.language.isoeng
dc.publisherAssoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial
dc.relation.ispartofOxidative Medicine And Cellular Longevity
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLow-Density-Lipoproteinen
dc.subjectElement-Binding Protein-2en
dc.subjectAmazonian Palm Berryen
dc.subjectNonalcoholic Steatohepatitisen
dc.subjectSerum Paraoxonaseen
dc.subjectOxidative Stressen
dc.subjectAntioxidant Enzymesen
dc.subjectLiver Steatosisen
dc.subjectVitamin-Cen
dc.subjectIn-Vitroen
dc.titleAcai (euterpe oleracea mart.) Upregulates paraoxonase 1 gene expression and activity with concomitant reduction of hepatic steatosis in high-fat diet-fed ratsen
dc.typeinfo:eu-repo/semantics/article
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