Genetic diversity of HIV

dc.contributor.authorDiaz, Ricardo Sobhie [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T11:48:31Z
dc.date.available2018-06-18T11:48:31Z
dc.date.issued1997-04-01
dc.description.abstractThe human immunodeficiency virus (HIV) is a retrovirus (Fam: Retroviridae), which is the causative agent of the devastating AIDS pandemics currently affecting millions of human beings. HIV rapidly evolves by several molecular mechanisms, such as mutation, hypermutation, insertions and deletions and recombination; all process actively contributing to its genetic diversity. This rapid evolutionary process, assisted by the rapid transmission through human populations, poses a significant challenge to the effective monitoring of HIV variation and AIDS control. Herein, the implications of genetic diversity related to the pathogenesis of HIV infection are addressed. The potential problems in its reliable detection by the antibody screening tests in current use, the role of a global genotyping surveillance, efforts to trace the progress of the worldwide epidemic and the rationale for future vaccines and drug trials will be discussed.en
dc.description.affiliationUNIV FED SAO PAULO, ESCOLA PAULISTA MED, RUA NAPOLEAO DE BARROS 715, 7 ANDAR, VILA CLEMENTIN, BR-04023062 SAO PAULO, BRAZIL
dc.description.affiliationUnifespUNIV FED SAO PAULO, ESCOLA PAULISTA MED, RUA NAPOLEAO DE BARROS 715, 7 ANDAR, VILA CLEMENTIN, BR-04023062 SAO PAULO, BRAZIL
dc.description.sourceWeb of Science
dc.format.extent69-75
dc.identifier.citationRevista De Microbiologia. Sao Paulo: Soc Brasileira Microbiologia, v. 28, n. 2, p. 69-75, 1997.
dc.identifier.issn0001-3714
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/45458
dc.identifier.wosWOS:A1997XU75900001
dc.language.isoeng
dc.publisherSoc Brasileira Microbiologia
dc.relation.ispartofRevista De Microbiologia
dc.rightsAcesso restrito
dc.subjectHIV-4en
dc.subjectgenetic diversityen
dc.subjectmolecular epidemiologyen
dc.titleGenetic diversity of HIVen
dc.typeArtigo
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