CARDIOVASCULAR ADJUSTMENTS IN LIMB RETRACTION PROVOKED BY NOXIOUS-STIMULATION IN DECEREBRATE AND SPINAL CATS - EVIDENCE FOR A SOMATOTOPIC ORGANIZATION

dc.contributor.authorCravo, Sergio Luiz [UNIFESP]
dc.contributor.authorLopes, Oswaldo Ubriaco [UNIFESP]
dc.contributor.authorFraga, CAB
dc.contributor.authorTimo-Iaria, César [UNIFESP]
dc.contributor.institutionFAC CIENCIAS MED SAO PAULO
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T14:28:10Z
dc.date.available2018-06-15T14:28:10Z
dc.date.issued1995-03-01
dc.description.abstractArterial blood pressure, heart rate and iliac blood flow were continuously recorded in 61 adult cats and their alteration induced by noxious stimulation of the interdigital spaces of the four limbs was studied in intact (anesthetized) and in decerebrate and spinal preparations. Noxious stimulation of any limb in the decerebrate animals provoked retraction 61% of the times and an increase of blood pressure and heart rate in approximately 80% of the stimulations. Stimulation of a hindlimb provoked an increase of blood flow in the same limb in about 80% of the stimulations, due to active vasodilation. Contralateral stimulation provoked a smaller increase of blood flow but with an increase in vascular resistance, indicating some degree of vasoconstriction. Stimulation of the forelimbs induced small increases of blood flow in the hindlimbs but the calculated vascular resistance was higher than the basal values, also indicating vasoconstriction. Neuromuscular blockade with gallamine did not affect the increase of hindlimb blood flow, suggesting a central regulation of the intricate distribution of blood to the limbs. The vasodilation was not due to activation of sympathetic cholinergic vasodilator neurons inasmuch as the blood flow responses were not affected by cholinergic blockade with atropine. In spinal animals, stimulation of any limb provoked small increases of blood pressure, extremely low degrees of tachycardia and an increase of hindlimb blood flow, with active vasodilation. Neuromuscular paralysis, however, abolished the adjustments of blood flow in the hindlimbs, indicating that metabolites and/or sensory information caused by muscle contraction induced them. In intact cats anesthetized with sodium pentobarbiturate, blood pressure and heart rate increased under noxious stimulation, although less than in the decerebrate animals. Nearly 40% of the stimulations provoked hypotension rather than hypertension. Blood flow increased due to stimulation of any limb but, as in the decerebrate preparation, there was active vasodilation in the ipsilateral hindlimb and vasoconstriction in the contralateral one.en
dc.description.affiliationFAC CIENCIAS MED SAO PAULO,DEPT CIENCIAS FISIOL,BR-01221020 SAO PAULO,SP,BRAZIL
dc.description.affiliationUNIV SAO PAULO,FAC MED,FISIOL CLIN LIM LAB 74,BR-00124690 SAO PAULO,SP,BRAZIL
dc.description.affiliationUNIV SAO PAULO,FAC MED,NEUROL EXPTL LIM LAB 45,BR-00124690 SAO PAULO,SP,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent385-396
dc.identifier.citationBrazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 28, n. 3, p. 385-396, 1995.
dc.identifier.issn0100-879X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43082
dc.identifier.wosWOS:A1995QV61600019
dc.language.isoeng
dc.publisherAssoc Bras Divulg Cientifica
dc.relation.ispartofBrazilian Journal Of Medical And Biological Research
dc.rightsAcesso restrito
dc.subjectHEART RATEen
dc.subjectBLOOD PRESSUREen
dc.subjectLIMB BLOOD FLOWen
dc.subjectDECEREBRATIONen
dc.subjectDEFENSIVE BEHAVIORSen
dc.titleCARDIOVASCULAR ADJUSTMENTS IN LIMB RETRACTION PROVOKED BY NOXIOUS-STIMULATION IN DECEREBRATE AND SPINAL CATS - EVIDENCE FOR A SOMATOTOPIC ORGANIZATIONen
dc.typeArtigo
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