Effectiveness of vesicoamniotic shunt in fetuses with congenital lower urinary tract obstruction: an updated systematic review and meta-analysis

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dc.citation.issue6
dc.citation.volume49
dc.contributor.authorNassr, A. A.
dc.contributor.authorShazly, S. A. M.
dc.contributor.authorAbdelmagied, A. M.
dc.contributor.authorAraujo Junior, E. [UNIFESP]
dc.contributor.authorTonni, G.
dc.contributor.authorKilby, M. D.
dc.contributor.authorRuano, R.
dc.coverageHoboken
dc.date.accessioned2020-07-13T11:53:04Z
dc.date.available2020-07-13T11:53:04Z
dc.date.issued2017
dc.description.abstractObjective To evaluate the effect on perinatal and postnatal survival of vesicoamniotic shunt (VAS) as treatment for fetal lower urinary tract obstruction (LUTO). Methods An electronic search of Ovid MEDLINE, Ovid EMBASE, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews and Scopus using relevant search terms was conducted from inception to June 2015 to identify studies comparing outcomes of VAS vs conservative management for treatment of LUTO. Cohort studies and clinical trials were considered eligible. Single-arm studies and studies that did not report survival were excluded. Sample size and language were not criteria for exclusion. Two reviewers extracted independently data in a standardized form, including study characteristics and results. Primary outcomes were perinatal and postnatal survival. Secondary outcome was postnatal renal function. Data on fetal survival were expressed as odds ratio (OR) and 95% CI. Results Of the 423 abstracts retrieved, nine studies were eligible for inclusion. These studies included 112 fetuses treated with VAS and 134 that were managed conservatively. There was heterogeneity in study design. Although the data demonstrated a difference in effect estimates between the study arms in terms of perinatal survival (OR, 2.54 (95% CI, 1.14-5.67)), there was no difference in 6-12-month survival (OR, 1.77 (95% CI, 0.25-12.71)) or 2-year survival (OR, 1.81 (95% CI, 0.09-38.03)). In addition, there was no difference in effect on postnatal renal function between fetuses that underwent intervention and those that did not (OR, 2.09 (95% CI, 0.74-5.94)). Conclusions Available data seem to support an advantage for perinatal survival in fetuses treated with VAS compared with conservative management. However, 1-2-year survival and outcome of renal function after VAS procedure remain uncertain. Further studies are necessary to evaluate the effectiveness of fetal intervention for LUTO based on different severity of the disease, due to the very low quality of the studies according to GRADE guidelines. Copyright (C) 2016 ISUOG. Published by John Wiley & Sons Ltd.en
dc.description.affiliationMayo Clin, Coll Med, Dept Obstet & Gynecol, Rochester, MN USA
dc.description.affiliationAssiut Univ Hosp, Womens Hlth Hosp, Assiut, Egypt
dc.description.affiliationBaylor Coll Med, Dept Obstet & Gynecol, Houston, TX 77030 USA
dc.description.affiliationTexas Childrens Fetal Ctr, Houston, TX USA
dc.description.affiliationUniv Fed Sao Paulo, Paulista Sch Med, Dept Obstet, Sao Paulo, Brazil
dc.description.affiliationAUSL Reggio Emilia, Dept Obstet & Gynecol, Prenatal Diagnost Serv, Reggio Emilia, Italy
dc.description.affiliationUniv Birmingham, Coll Med & Dent Sci, Inst Metab & Syst Res, Ctr Womens & Childrens Hlth, Birmingham, W Midlands, England
dc.description.affiliationMayo Clin, Fetal Diagnost & Therapeut Ctr, Rochester, MN USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Paulista Sch Med, Dept Obstet, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent696-703
dc.identifierhttp://dx.doi.org/10.1002/uog.15988
dc.identifier.citationUltrasound In Obstetrics & Gynecology. Hoboken, v. 49, n. 6, p. 696-703, 2017.
dc.identifier.doi10.1002/uog.15988
dc.identifier.issn0960-7692
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54377
dc.identifier.wosWOS:000402642000005
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofUltrasound In Obstetrics & Gynecology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectfetal obstructive uropathyen
dc.subjectposterior urethral valveen
dc.subjectvesicoamniotic shunten
dc.titleEffectiveness of vesicoamniotic shunt in fetuses with congenital lower urinary tract obstruction: an updated systematic review and meta-analysisen
dc.typeinfo:eu-repo/semantics/article
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