Intrastromal corneal ring--one-year results of first implants in humans: a preliminary nonfunctional eye study

dc.contributor.authorNosé, Walton [UNIFESP]
dc.contributor.authorNeves, Renato Augusto [UNIFESP]
dc.contributor.authorSchanzlin, David J.
dc.contributor.authorBelfort, Rubens Junior [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T11:35:31Z
dc.date.available2018-06-18T11:35:31Z
dc.date.issued1993-11-01
dc.description.abstractBACKGROUND: The Intrastromal Corneal Ring (ICR) is a new investigational medical device designed to alter corneal curvature without surgical intervention in the central cornea. The ring is inserted between the layers of the stroma in the cornea's periphery at two-thirds depth through an approximately 2-millimeter incision.METHODS: To investigate the safety and refractive effect of implanting an ICR of a given thickness (0.30 mm) and outer diameter (7.70 mm) into human corneas, an ICR was implanted into one nonfunctional eye of each of three patients during the period of March to May, 1991. One predesignated ICR was successfully explanted 5 months after implantation to evaluate the feasibility of ICR removal and to observe the effect of ring removal on corneal curvature. Patients were followed for 1 year after the initial implant procedure.RESULTS: The three implant procedures and postoperative courses proceeded without any significant complications. Approximately 2.00 D of central corneal flattening was achieved in all eyes. No adverse reactions or other medically-significant complications were observed over a 1-year follow-up period. The patient who underwent ICR removal experienced no perioperative complications, and the patient's cornea has remained stable with a return to its preoperative curvature.CONCLUSION: Although this study is preliminary and limited in scope, we have demonstrated that the ICR can be tolerated safely in the human cornea and results in a flattening of the corneal curvature that is stable for up to a year after insertion. The successful removal of the ICR begins to establish reversibility of the procedure and induced refractive effect.en
dc.description.affiliationSAO PAULO HOSP,ESCOLA PAULISTA MED,DEPT OPHTHALMOL,SAO PAULO,BRAZIL
dc.description.affiliationUnifespSAO PAULO HOSP,ESCOLA PAULISTA MED,DEPT OPHTHALMOL,SAO PAULO,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent452-458
dc.identifierhttp://www.healio.com/ophthalmology/journals/jrs/1993-11-9-6/%7Bb5034fae-d89d-462a-8668-6d602ea81214%7D/intrastromal-corneal-ring-one-year-results-of-first-implants-in-humans-a-preliminary-nonfunctional-eye-study
dc.identifier.citationRefractive And Corneal Surgery. Thorofare: Slack Inc, v. 9, n. 6, p. 452-458, 1993.
dc.identifier.doi10.3928/1081-597X-19931101-09
dc.identifier.issn0883-0444
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/45188
dc.identifier.wosWOS:A1993MQ73700007
dc.language.isoeng
dc.publisherSlack Inc
dc.relation.ispartofRefractive And Corneal Surgery
dc.rightsAcesso restrito
dc.titleIntrastromal corneal ring--one-year results of first implants in humans: a preliminary nonfunctional eye studyen
dc.typeArtigo
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