Eosinophilic inflammation in allergic asthma

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dc.contributor.authorPossa, Samantha S.
dc.contributor.authorLeick, Edna A.
dc.contributor.authorPrado, Carla Maximo [UNIFESP]
dc.contributor.authorMartins, Milton A.
dc.contributor.authorTiberio, Iolanda F. L. C.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:30:57Z
dc.date.available2016-01-24T14:30:57Z
dc.date.issued2013-01-01
dc.description.abstractEosinophils are circulating granulocytes involved in pathogenesis of asthma. A cascade of processes directed by Th2 cytokine producing T-cells influence the recruitment of eosinophils into the lungs. Furthermore, multiple elements including interleukin (IL)-5, IL-13, chemoattractants such as eotaxin, Clara cells, and CC chemokine receptor (CCR)3 are already directly involved in recruiting eosinophils to the lung during allergic inflammation. Once recruited, eosinophils participate in the modulation of immune response, induction of airway hyperresponsiveness and remodeling, characteristic features of asthma. Various types of promising treatments for reducing asthmatic response are related to reduction in eosinophil counts both in human and experimental models of pulmonary allergic inflammation, showing that the recruitment of these cells really plays an important role in the pathophysiology of allergic diseases such asthma.en
dc.description.affiliationUniv São Paulo, Sch Med, Dept Med, BR-01246 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biol Sci, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biol Sci, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.3389/fphar.2013.00046
dc.identifier.citationFrontiers in Pharmacology. Lausanne: Frontiers Research Foundation, v. 4, 9 p., 2013.
dc.identifier.doi10.3389/fphar.2013.00046
dc.identifier.fileWOS000347011700045.pdf
dc.identifier.issn1663-9812
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35738
dc.identifier.wosWOS:000347011700045
dc.language.isoeng
dc.publisherFrontiers Research Foundation
dc.relation.ispartofFrontiers in Pharmacology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectairway remodelingen
dc.subjectasthmaen
dc.subjecteosinophilsen
dc.subjectexperimental models of asthmaen
dc.subjectinflammationen
dc.subjectrespiratory hypersensitivityen
dc.titleEosinophilic inflammation in allergic asthmaen
dc.typeinfo:eu-repo/semantics/article
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