Observational retrospective study evaluating the effects of oral isotretinoin in keloids and hypertrophic scars

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dc.citation.issue11
dc.citation.volume55
dc.contributor.authorGuadanhim, Lilia Ramos dos Santos [UNIFESP]
dc.contributor.authorGoncalves, Rubens Guilherme [UNIFESP]
dc.contributor.authorBagatin, Edileia [UNIFESP]
dc.coverageHoboken
dc.date.accessioned2020-07-31T12:47:24Z
dc.date.available2020-07-31T12:47:24Z
dc.date.issued2016
dc.description.abstractBackground Acne vulgaris is a chronic inflammatory disease characterized by noninflammatory and inflammatory lesions that can cause scarring. Oral isotretinoin is the current recommended treatment for moderate and severe casesen
dc.description.abstracthowever, there are reports of possible influences on the healing process of the skin, leading to an increase in the risk for hypertrophic scars and keloids. This hypothesis, although unproven, represents a contraindication to the treatment of acne scars during the 6-12 months after the cessation of isotretinoin. Objectives The aim of this study was to investigate the prevalences of hypertrophic scars and keloids in acne patients treated with oral isotretinoin. Methods Three data collection strategies were used: (i) clinical examination of patients with acne vulgaris, exposed or unexposed to oral isotretinoin, focusing on the occurrence of hypertrophic scars and/or keloidsen
dc.description.abstract(ii) telephone interviews of patients using oral isotretinoin to treat acne vulgaris on the occurrence or worsening of keloidsen
dc.description.abstractand (iii) clinical examination of patients with previous use of oral isotretinoin followed at a specific keloid treatment clinic. Results The resulting data showed no differences in wound healing. Conclusions These findings may indicate that the occurrence of hypertrophic scars or keloids in patients using oral isotretinoin is an undesirable event arising from an individual response and may be related to inflammatory acne evolution.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Dermatol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespDepartment of Dermatology, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent1255-1258
dc.identifierhttp://dx.doi.org/10.1111/ijd.13317
dc.identifier.citationInternational Journal Of Dermatology. Hoboken, v. 55, n. 11, p. 1255-1258, 2016.
dc.identifier.doi10.1111/ijd.13317
dc.identifier.issn0011-9059
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56810
dc.identifier.wosWOS:000385763500025
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofInternational Journal Of Dermatology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titleObservational retrospective study evaluating the effects of oral isotretinoin in keloids and hypertrophic scarsen
dc.typeinfo:eu-repo/semantics/article
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