Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys

Página do item simplificado
dc.contributor.authorBerro, Lais F. [UNIFESP]
dc.contributor.authorDiaz, Maylen Perez
dc.contributor.authorMaltbie, Eric
dc.contributor.authorHowell, Leonard L.
dc.date.accessioned2019-08-19T11:49:38Z
dc.date.available2019-08-19T11:49:38Z
dc.date.issued2017
dc.description.abstractAccumulating evidence shows that the serotonergic system plays a major role in psychostimulant abuse through its interactions with the dopaminergic system. Studies indicate that serotonin 5-HT2C receptors are one of the main classes of receptors involved in mediating the influence of serotonin in drug abuse. The aim of the present study was to evaluate the effects of the selective serotonin 5-HT2C receptor agonist WAY163909 on the behavioral neuropharmacology of cocaine and methamphetamine in adult rhesus macaques. Cocaine or methamphetamine self-administration and reinstatement were evaluated under second-order and fixed-ratio schedules of reinforcement, respectively. Cocaine- and methamphetamine-induced increases in dopamine were assessed through in vivo microdialysis targeting the nucleus accumbens. Pretreatment with WAY163909 dose-dependently attenuated cocaine and methamphetamine self-administration and drug-induced reinstatement of extinguished behavior previously maintained by cocaine or methamphetamine delivery. In an additional experiment, WAY163909 induced a dose-dependent attenuation of cocaine- or methamphetamine-induced dopamine overflow in the nucleus accumbens. Our data indicate that selective 5-HT2C receptor activation decreases drug intake and drug-seeking behavior in nonhuman primate models of psychostimulant abuse through neurochemical mechanisms involved in the modulation of mesolimbic dopamine.en
dc.description.affiliationEmory Univ, Yerkes Natl Primate Res Ctr, 954 Gatewood Rd NE, Atlanta, GA 30329 USA
dc.description.affiliationUniv Fed São Paulo, Dept Psychobiol, São Paulo, SP, Brazil
dc.description.affiliationEmory Univ, Dept Psychiat & Behav Sci, Yerkes Natl Primate Res Ctr, 954 Gatewood Rd NE, Atlanta, GA 30329 USA
dc.description.affiliationUnifespUniv Fed São Paulo, Dept Psychobiol, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipUSPHS
dc.description.sponsorshipAFIP
dc.description.sponsorshipFAPESP
dc.description.sponsorshipIDUSPHS: DA10344
dc.description.sponsorshipIDUSPHS: DA031246
dc.description.sponsorshipIDUSPHS: ODP51OD11132
dc.description.sponsorshipIDFAPESP: 2015/16109-7
dc.description.sponsorshipIDFAPESP: 2015/25482-3
dc.format.extent2607-2617
dc.identifierhttp://dx.doi.org/10.1007/s00213-017-4653-2
dc.identifier.citationPsychopharmacology. New York, v. 234, n. 17, p. 2607-2617, 2017.
dc.identifier.doi10.1007/s00213-017-4653-2
dc.identifier.issn0033-3158
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51363
dc.identifier.wosWOS:000407397200008
dc.language.isoeng
dc.publisherSpringer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCocaineen
dc.subjectMethamphetamineen
dc.subjectSelf-administrationen
dc.subjectReinstatementen
dc.subjectIn vivo microdialysisen
dc.subjectRhesus monkeysen
dc.titleEffects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeysen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos