Effect of saline infusion for the maintenance of blood volume on pulmonary gas exchange during temporary abdominal aortic occlusion

dc.contributor.authorAmorim, Fabio Ferreira [UNIFESP]
dc.contributor.authorPinheiro, Bruno do Valle [UNIFESP]
dc.contributor.authorBeppu, Osvaldo Shigueomi [UNIFESP]
dc.contributor.authorRomaldini, Helio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:36:44Z
dc.date.available2015-06-14T13:36:44Z
dc.date.issued2007-03-01
dc.description.abstractWe analyzed the effects of saline infusion for the maintenance of blood volume on pulmonary gas exchange in ischemia-reperfusion syndrome during temporary abdominal aortic occlusion in dogs. We studied 20 adult mongrel dogs weighing 12 to 23 kg divided into two groups: ischemia-reperfusion group (IRG, N = 10) and IRG submitted to saline infusion for the maintenance of mean pulmonary arterial wedge pressure between 10 and 20 mmHg (IRG-SS, N = 10). All animals were anesthetized and maintained on spontaneous ventilation. After obtaining baseline measurements, occlusion of the supraceliac aorta was performed by the inflation of a Fogarty catheter. After 60 min of ischemia, the balloon was deflated and the animals were observed for another 60 min of reperfusion. The measurements were made at 10 and 45 min of ischemia, and 5, 30, and 60 min of reperfusion. Pulmonary gas exchange was impaired in the IRG-SS group as demonstrated by the increase of the alveolar-arterial oxygen difference (21 ± 14 in IRG-SS vs 11 ± 8 in IRG after 60 min of reperfusion, P = 0.004 in IRG-SS in relation to baseline values) and the decrease of oxygen partial pressure in arterial blood (58 ± 15 in IRG-SS vs 76 ± 15 in IRG after 60 min of reperfusion, P = 0.001 in IRG-SS in relation to baseline values), which was correlated with the highest degree of pulmonary edema in morphometric analysis (0.16 ± 0.06 in IRG-SS vs 0.09 ± 0.04 in IRG, P = 0.03 between groups). There was also a smaller ventilatory compensation of metabolic acidosis after the reperfusion. We conclude that infusion of normal saline worsened the gas exchange induced by pulmonary reperfusion injury in this experimental model.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Medicina
dc.description.affiliationUnifespUNIFESP, EPM, Depto. de Medicina
dc.description.sourceSciELO
dc.format.extent333-341
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2006005000079
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 3, p. 333-341, 2007.
dc.identifier.doi10.1590/S0100-879X2006005000079
dc.identifier.fileS0100-879X2007000300008.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2007000300008
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/3558
dc.identifier.wosWOS:000244667700008
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsAcesso aberto
dc.subjectReperfusion lesionen
dc.subjectFluid resuscitationen
dc.subjectPulmonary gas exchangeen
dc.subjectLung edemaen
dc.titleEffect of saline infusion for the maintenance of blood volume on pulmonary gas exchange during temporary abdominal aortic occlusionen
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