Effect of montelukast on exhaled nitric oxide and nonvolatile markers of inflammation in mild asthma

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dc.contributor.authorSandrini, A.
dc.contributor.authorFerreira, I. M.
dc.contributor.authorGutierrez, C.
dc.contributor.authorJardim, Jose R. [UNIFESP]
dc.contributor.authorZamel, N.
dc.contributor.authorChapman, K. R.
dc.contributor.institutionUniv Toronto
dc.contributor.institutionToronto Western Hosp
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:34:04Z
dc.date.available2016-01-24T12:34:04Z
dc.date.issued2003-10-01
dc.description.abstractStudy objectives: Leukotriene receptor antagonists appear to exert anti-inflammatory activity in asthma. We undertook the present study to evaluate the effect of montelukast on levels of exhaled nitric oxide (ENO) and two inflammatory markers, hydrogen peroxide (H2O2), and cysteinyl. leukotrienes (cys-LTs), in the exhaled breath condensate of subjects with mild asthma.Patients: Twenty stable subjects with mild asthma (15 women and 5 men; mean [+/-SD] age, 34.8 +/- 12.6 years) were included in the study. Intervention: A 1-week run-in period was followed by 2 weeks of treatment (with montelukast or placebo) that was administered in randomized, double-blind, crossover fashion. One week of washout followed each treatment arm.Results: Montelukast significantly reduced the levels of ENO from baseline (median, 52.5 parts per billion [ppb]; 25th to 75th percentile, 37.8 to 101.8 ppb) during the entire treatment period (ie, day 1 to day 14), with the effect measurable as early as day I (median, 45.9 ppb; 25th to 75th percentile, 29.3 to 92.5 ppb) and with the maximal effect being observed on day 7 (median, 35.7 ppb; 25th to 75th percentile, 27.6 to 66.6 ppb). the levels of ENO did not change significantly with placebo therapy. Montelukast improved symptom score and reduced peak expiratory flow (PEF) variability. Changes in PEF variability correlated positively with changes in ENO (r = 0.46; p = 0.04). No significant changes in FEV1 or concentration of H2O2 in the exhaled breath condensate were observed. Levels of cys-LTs were undetectable in the exhaled breath condensate.Conclusions: We concluded that montelukast reduces the levels of ENO in patients with mild asthma, a finding that is compatible with an anti-inflammatory effect of montelukast, and that ENO appears to be more sensitive in detecting this effect, than FEV1 and H2O2 levels in the exhaled breath condensate.en
dc.description.affiliationUniv Toronto, Hlth Network, Asthma & Airway Ctr, Div Resp Med, Toronto, ON M5T 2S8, Canada
dc.description.affiliationToronto Western Hosp, Asthma & Airway Ctr, Toronto, ON M5T 2S8, Canada
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulisa Med, Respirol Div, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulisa Med, Respirol Div, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1334-1340
dc.identifierhttp://dx.doi.org/10.1378/chest.124.4.1334
dc.identifier.citationChest. Northbrook: Amer Coll Chest Physicians, v. 124, n. 4, p. 1334-1340, 2003.
dc.identifier.doi10.1378/chest.124.4.1334
dc.identifier.issn0012-3692
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27424
dc.identifier.wosWOS:000186002500023
dc.language.isoeng
dc.publisherAmer Coll Chest Physicians
dc.relation.ispartofChest
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectasthmaen
dc.subjectbreath testsen
dc.subjecthydrogen peroxideen
dc.subjectleukotriene antagonistsen
dc.subjectleukotrienesen
dc.subjectnitric oxideen
dc.titleEffect of montelukast on exhaled nitric oxide and nonvolatile markers of inflammation in mild asthmaen
dc.typeinfo:eu-repo/semantics/article
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