How Safe Is Thromboprophylaxis in Abdominoplasty?

dc.contributor.authorDini, Gal Moreira [UNIFESP]
dc.contributor.authorCorsi Ferreira, Maria Carolina
dc.contributor.authorAlbuquerque, Luciana Gianini
dc.contributor.authorFerreira, Lydia Masako
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.abstractBackground: Deep vein thrombosis and its most dangerous outcome, pulmonary embolism, are complications with a high incidence in hospitalized patients. in plastic surgery, abdominoplasty is the aesthetic surgery more frequently associated with deep vein thrombosis condition. This study aimed to test the efficacy and safety of oral rivaroxaban for the prevention of venous thromboembolism after abdominoplasty in patients considered to be at risk.Methods: in a randomized, double-blind study, 40 patients undergoing abdominoplasty were assigned to receive either oral rivaroxaban (10 mg) or oral placebo once daily for 10 days, beginning 6 to 8 hours after surgery. Results: the study was interrupted after 27 operations due to systematic complications. the population operated on was composed of women with a mean age of 38 years. Most patients were Caucasian (85 percent) and had amean body mass index of 28. the average overall rate of complications was 29.6 percent (large hematomas requiring drainage), and all complications were seen in the study group, with none in the control group.Conclusions: Plastic surgery procedures in which large detachment is planned in patients with a moderate risk of deep venous thrombosis should be evaluated with regard to the risk and benefit of thromboembolism prophylaxis. Other measures must be applied and eventually contraindicate a surgical procedure. Further research is needed to complement the data from this work. (Plast. Reconstr. Surg. 130: 851e, 2012.)en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Surg, Div Plast Surg, BR-18031080 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Surg, Div Plast Surg, BR-18031080 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.identifier.citationPlastic and Reconstructive Surgery. Philadelphia: Lippincott Williams & Wilkins, v. 130, n. 6, p. 851E-857E, 2012.
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofPlastic and Reconstructive Surgery
dc.rightsAcesso restrito
dc.titleHow Safe Is Thromboprophylaxis in Abdominoplasty?en