PARTICIPATION of the ADRENAL-GLAND in the ANTIINFLAMMATORY EFFECT of POLYUNSATURATED DIETS

dc.contributor.authorSilveira, Vera Lucia Flor [UNIFESP]
dc.contributor.authorLimaos, E. A.
dc.contributor.authorNunes, D. W.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T11:40:26Z
dc.date.available2016-01-24T11:40:26Z
dc.date.issued1995-09-01
dc.description.abstractTHE effect of an n-3 (fish) and n-6 (soybean) fatty acid-rich diet on carrageenin paw oedema in rats, and the participation of adrenal gland, corticosterone and alpha(2)-macroglobulin (alpha(2)-M) in this process were studied. A significant inhibition of carrageenin oedema was observed not only in rats fed a diet rich in fish oil but also in the soybean group. alpha(2)-M was not detectable before carrageenin injection, suggesting that this putative anti-inflammatory factor does not participate in the observed anti-inflammatory effect. Corticosterone levels were higher in fat-fed than in control rats, before carrageenin stimulus and adrenalectomy abolished the anti-inflammatory response in fat-fed animals, showing the important role of the adrenocortical hormones in this process.en
dc.description.affiliationUniversidade Federal de São Paulo,ESCOLA PAULISTA MED,DEPT PHYSIOL,São Paulo,BRAZIL
dc.description.affiliationUnifespUniversidade Federal de São Paulo,ESCOLA PAULISTA MED,DEPT PHYSIOL,São Paulo,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent359-363
dc.identifierhttp://dx.doi.org/10.1155/S0962935195000585
dc.identifier.citationMediators of Inflammation. London: Rapid Science Publishers, v. 4, n. 5, p. 359-363, 1995.
dc.identifier.doi10.1155/S0962935195000585
dc.identifier.fileWOSA1995TC00200008.pdf
dc.identifier.issn0962-9351
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25522
dc.identifier.wosWOS:A1995TC00200008
dc.language.isoeng
dc.publisherRapid Science Publishers
dc.relation.ispartofMediators of Inflammation
dc.rightsAcesso aberto
dc.subjectCARRAGEENAN EDEMAen
dc.subjectCORTICOSTEROIDSen
dc.subjectALPHA(2)-MACROGLOBULINen
dc.subjectPOLYUNSATURATED FATTY ACIDSen
dc.titlePARTICIPATION of the ADRENAL-GLAND in the ANTIINFLAMMATORY EFFECT of POLYUNSATURATED DIETSen
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