Enhanced Synaptic Connectivity in the Dentate Gyrus during Epileptiform Activity: Network Simulation

dc.contributor.authorAlmeida Franca, Keite Lira de
dc.contributor.authorGuimaraes de Almeida, Antonio-Carlos
dc.contributor.authorCatelli Infantosi, Antonio Fernando
dc.contributor.authorDuarte, Mario Antonio
dc.contributor.authorSilveira, Gilcelio Amaral da
dc.contributor.authorScorza, Fulvio Alexandre [UNIFESP]
dc.contributor.authorArida, Ricardo Mario [UNIFESP]
dc.contributor.authorCavalheiro, Esper Abrao [UNIFESP]
dc.contributor.authorRodrigues, Antonio Marcio
dc.contributor.institutionUniversidade Federal de Sergipe (UFS)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:30:55Z
dc.date.available2016-01-24T14:30:55Z
dc.date.issued2013-01-01
dc.description.abstractStructural rearrangement of the dentate gyrus has been described as the underlying cause of many types of epilepsies, particularly temporal lobe epilepsy. It is said to occur when aberrant connections are established in the damaged hippocampus, as described in human epilepsy and experimental models. Computer modelling of the dentate gyrus circuitry and the corresponding structural changes has been used to understand how abnormal mossy fibre sprouting can subserve seizure generation observed in experimental models when epileptogenesis is induced by status epilepticus. the model follows the McCulloch-Pitts formalism including the representation of the nonsynaptic mechanisms. the neuronal network comprised granule cells, mossy cells, and interneurons. the compensation theory and the Hebbian and anti-Hebbian rules were used to describe the structural rearrangement including the effects of the nonsynaptic mechanisms on the neuronal activity. the simulations were based on neuroanatomic data and on the connectivity pattern between the cells represented. the results suggest that there is a joint action of the compensation theory and Hebbian rules during the inflammatory process that accompanies the status epilepticus. the structural rearrangement simulated for the dentate gyrus circuitry promotes speculation about the formation of the abnormal mossy fiber sprouting and its role in epileptic seizures.en
dc.description.affiliationUniv Fed Sao Joao Rei UFSJ, Dept Engn Biossistemas, Lab Neurociencia Expt Computac, Sao Joao Del Rei, MG, Brazil
dc.description.affiliationUniv Fed Rio Janeiro UFRJ COPPE, Programa Engn Biomed, Rio de Janeiro, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, EPM, Disciplina Neurol Expt, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, EPM, Disciplina Neurofisiol & Fisiol Exercicio, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, EPM, Disciplina Neurol Expt, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, EPM, Disciplina Neurofisiol & Fisiol Exercicio, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipINNT
dc.format.extent19
dc.identifierhttp://dx.doi.org/10.1155/2013/949816
dc.identifier.citationComputational Intelligence and Neuroscience. New York: Hindawi Publishing Corporation, 19 p., 2013.
dc.identifier.doi10.1155/2013/949816
dc.identifier.fileWOS000334111200001.pdf
dc.identifier.issn1687-5265
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35711
dc.identifier.wosWOS:000334111200001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofComputational Intelligence and Neuroscience
dc.rightsAcesso aberto
dc.titleEnhanced Synaptic Connectivity in the Dentate Gyrus during Epileptiform Activity: Network Simulationen
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