Mimosa (Mimosa caesalpiniifolia) prevents oxidative DNA damage induced by cadmium exposure in Wistar rats

dc.contributor.authorSilva, Marcelo Jose Dias
dc.contributor.authorVilegas, Wagner
dc.contributor.authorSilva, Marcelo Aparecido da
dc.contributor.authorMoura, Carolina Foot Gomes de [UNIFESP]
dc.contributor.authorRibeiro, Flavia Andressa Pidone [UNIFESP]
dc.contributor.authorSilva, Victor Hugo Pereira da [UNIFESP]
dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.contributor.institutionSão Paulo State Univ
dc.contributor.institutionUniv Fed Alfenas
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:38:17Z
dc.date.available2016-01-24T14:38:17Z
dc.date.issued2014-12-01
dc.description.abstractThe Mimosa (Mimosa caesalpiniifolia) is a plant native from South America; it is used in the traditional medicine systems for treating bacterial, fungal, parasitic and inflammatory conditions. the aim of this study was to evaluate the antigenotoxic and antioxidant activities induced by mimosa (M. caesalpiniifolia) in multiple rodent organs subjected to intoxication with cadmium chloride. A total of 40 Wistar rats (8 weeks old, 250 g) were distributed into eight groups (n = 5), as follows: Control group (non-treated group, CTRL); Cadmium exposed group (Cd); cadmium exposure and treated with extract at 62.5 mg/kg/day; cadmium exposure and treated with extract at 125 mg/kg/day; cadmium exposure and treated with extract at 250 mg/kg/day; cadmium exposure and treated with ethyl acetate fraction at 62.5 mg/kg/day. for evaluating the toxicogenetic potential of mimosa, two groups were included in the study being treated with extract at 250 mg/kg/day and acetate fraction of mimosa at 62 mg/kg/day, only. Extract of mimosa at concentrations of 62.5 and 125mg decreased DNA damage in animals intoxicated with cadmium when compared to cadmium group. in a similar manner, treatment with ethyl acetate fraction of mimosa at 62.5mg concentration in animals previously exposed to cadmium reduced genetic damage in peripheral blood cells. in a similar manner, the treatment with ethyl acetate fraction reduced DNA damage in liver cells. Oxidative DNA damage was reduced to animals exposed to cadmium and treated with 125mg of extract as well as those intoxicated to cadmium and treated with 62.5 of acetate fraction of mimosa. Taken together, our results indicate that mimosa prevents genotoxicity induced by cadmium exposure in liver and peripheral blood cells of rats as a result of antioxidant activity.en
dc.description.affiliationSão Paulo State Univ, UNESP, Sao Vicente, SP, Brazil
dc.description.affiliationUniv Fed Alfenas, UNIFAL, Dept Food & Drug, Alfenas, MG, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, Dept Biosci, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, Dept Biosci, BR-11060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent567-574
dc.identifierhttps://dx.doi.org/10.3109/15376516.2014.955230
dc.identifier.citationToxicology Mechanisms and Methods. London: Informa Healthcare, v. 24, n. 8, p. 567-574, 2014.
dc.identifier.doi10.3109/15376516.2014.955230
dc.identifier.issn1537-6516
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/38539
dc.identifier.wosWOS:000344363200006
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofToxicology Mechanisms and Methods
dc.rightsAcesso restrito
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.subjectAntioxidant activityen
dc.subjectCadmiumen
dc.subjectGenotoxicityen
dc.subjectMimosaen
dc.subjectRaten
dc.titleMimosa (Mimosa caesalpiniifolia) prevents oxidative DNA damage induced by cadmium exposure in Wistar ratsen
dc.typeArtigo
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