Postprandial Proximal Gastric Acid Pocket in Patients after Roux-En-Y Gastric Bypass

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dc.contributor.authorHerbella, Fernando A. M. [UNIFESP]
dc.contributor.authorVicentine, Fernando P. P. [UNIFESP]
dc.contributor.authorDel Grande, Jose C. [UNIFESP]
dc.contributor.authorPatti, Marco G.
dc.contributor.authorArasaki, Carlos H. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Chicago
dc.date.accessioned2016-01-24T14:05:37Z
dc.date.available2016-01-24T14:05:37Z
dc.date.issued2010-11-01
dc.description.abstractAn unbuffered postprandial proximal gastric acid pocket (PPGAP) has been noticed in normal individuals and patients with gastroesophageal reflux disease (GERD). the role of gastric anatomy in the physiology of the PPGAP remains unclear. It is also unclear whether operations that control GERD, such as Roux-en-Y gastric bypass (RYGB) and Nissen fundoplication, change the PPGAP.This study aims to analyze the presence of PPGAP in patients submitted to RYGB.Fifteen patients who had a RYGB for morbid obesity (mean age 53 years, 14 females, mean time from operation 3 years) were studied. All patients were free of foregut symptoms. Patients underwent a high-resolution manometry to identify the location of the lower border of the lower esophageal sphincter (LBLES). A station pull-through pH monitoring was performed from 5 cm below the LBLES to the LBLES in increments of 1 cm in a fasting state and 10 min after a standardized fatty meal (40 g of chocolate, 50% fat).Acidity was not detected in the stomach of four patients before meal. After meal, PPGAP was not found in eight patients. in three patients, a PPGAP was noted with an extension of 1 to 3 cm.PPGAP is present in a minority of patients after RYGB; this finding may explain part of the GERD control after RYGB and that the gastric fundus may play a role in the genesis of the PPGAP.en
dc.description.affiliationHosp São Paulo, Div Esophagus & Stomach, BR-04037003 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Surg, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationUniv Chicago, Dept Surg, Chicago, IL 60637 USA
dc.description.affiliationUnifespHosp São Paulo, Div Esophagus & Stomach, BR-04037003 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Surg, Escola Paulista Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2007/07940-8
dc.format.extent1742-1745
dc.identifierhttp://dx.doi.org/10.1007/s11605-010-1309-5
dc.identifier.citationJournal of Gastrointestinal Surgery. New York: Springer, v. 14, n. 11, p. 1742-1745, 2010.
dc.identifier.doi10.1007/s11605-010-1309-5
dc.identifier.issn1091-255X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33028
dc.identifier.wosWOS:000283135000023
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal of Gastrointestinal Surgery
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectGastroesophageal refluxen
dc.subjectRoux-en-Y gastric bypassen
dc.subjectAcid pocketen
dc.titlePostprandial Proximal Gastric Acid Pocket in Patients after Roux-En-Y Gastric Bypassen
dc.typeinfo:eu-repo/semantics/article
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