The water extract of Coleus barbatus Benth decreases gastric secretion in rats

Página do item simplificado
dc.contributor.authorFischman, Lygia Adriane [UNIFESP]
dc.contributor.authorSkorupa, Ladislau Araújo
dc.contributor.authorSouccar, Caden [UNIFESP]
dc.contributor.authorLapa, Antonio José [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionEMBRAPA CENARGEM
dc.date.accessioned2015-06-14T13:24:20Z
dc.date.available2015-06-14T13:24:20Z
dc.date.issued1991-01-01
dc.description.abstractColeus barbatus (Labiatae) Benth is popularly used in Brazil for the healing of liver and stomach diseases. The water extract (WE 1 to 10 g/Kg, p.o.) of stem and leaves given to rats and mice did not induce signs of intoxication. Preveious treatment of mice with WE (1 g/kg, p.o.) shortened the sleeping time induced by pentobarbital (50 mg/Kg, i.p.) by 37 por cento, althoyugh the extract alone did not increase the spontaneous activity nor did it induce hyperexcitability. In mice WE (2 g/Kg, p.o.) increased the intestinal transit of charcoal by 30 por cento, while reduced gastric secretions ion rats treated with WE (2g/Kg intraduodenal) 3,9 ± 1.0 to 0.5 ± 0.2 ml/4h, respectively). The treatment also reduced the total acid secretion from 34.4 ± 11.0 to 2.7 ± 0.5 mEq/l and raisedgastric pH from 2.2 ± 0.3 to 6.5 ± 0.8. Treatment with WE (2g/Kg, p.o.) protected against gastric ulcers induced by stress (5.3 ± 1.6 and 1.5 ± 0.5 ulcers/cm²), but did nor protect against indonethacin induced ulcers. The results show that the water extract of C barbatus Benth produces mild stimulation of thecentral nervous system and increases intestinal movements. The extract also reduces gastric secretion indicating an antidyspeptic activity, and protects against gastric ulcers induced by stress.en
dc.description.affiliationEscola Paulista de Medicina Departamento de Farmacologia Setor de Produtos Natuais
dc.description.affiliationEMBRAPA CENARGEM
dc.description.affiliationUnifespUNIFESP, EPM, Depto. de Farmacologia Setor de Produtos Natuais
dc.description.sourceSciELO
dc.format.extent141-143
dc.identifierhttp://dx.doi.org/10.1590/S0074-02761991000600032
dc.identifier.citationMemórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 86, p. 141-143, 1991.
dc.identifier.doi10.1590/S0074-02761991000600032
dc.identifier.fileS0074-02761991000600032.pdf
dc.identifier.issn0074-0276
dc.identifier.scieloS0074-02761991000600032
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/269
dc.identifier.wosWOS:A1991GN58900032
dc.language.isoeng
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde
dc.relation.ispartofMemórias do Instituto Oswaldo Cruz
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectColeus barbatusen
dc.subjectboldusen
dc.subjectgastric secretionen
dc.subjectmedicinal planten
dc.titleThe water extract of Coleus barbatus Benth decreases gastric secretion in ratsen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
S0074-02761991000600032.pdf
Tamanho:
170.86 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos