PROFILE of PROSTAGLANDIN LEVELS in the RAT HIPPOCAMPUS in PILOCARPINE MODEL of EPILEPSY

dc.contributor.authorNaffah-mazzacoratti, M. G.
dc.contributor.authorBellissimo, M. I.
dc.contributor.authorCavalheiro, E. A.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T11:40:28Z
dc.date.available2016-01-24T11:40:28Z
dc.date.issued1995-12-01
dc.description.abstractPilocarpine (PILO) administered to rats acutely induces status epilepticus (acute period), which is followed by a transient seizure-free period (silent period), and finally by a chronic phase of spontaneous recurrent seizures (chronic period, SRS) that lasts for the rest of animal's life. Hippocampal neurochemical changes following PILO administration include alteration in monoamines and amino acids content during all phases of this epilepsy model. the present work was delineated to study the content df prostaglandins (PG) levels in hippocampus during the three phases of this model. the levels of PG E(2), PG F-2 alpha and PG D-2 were measured by radioimmunoassay 1 h after PILO, 5 h after PILO, during the silent period, and interictally into the chronic period. the results show, in hippocampus of rats, increase of PG F-2 alpha and PG D-2 during status epilepticus, increase of PG D-2 during the silent period and increase of PG E(2) and PG D-2 during the chronic phase, when compared with control group. These changes match previously reported alteration in monoamines and amino acid levels, showing that altered neurotransmission is accompanied by changes in second messengers and enzyme activity related to PG production during all phases of this epilepsy model.en
dc.description.affiliationUNIFESP,ESCOLA PAULISTA MED,DISCIPLINA NEUROL EXPTL,RUA BOTUCATU 862,BR-04023900 São Paulo,SP,BRAZIL
dc.description.affiliationUnifespUNIFESP,ESCOLA PAULISTA MED,DISCIPLINA NEUROL EXPTL,RUA BOTUCATU 862,BR-04023900 São Paulo,SP,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent461-466
dc.identifierhttp://dx.doi.org/10.1016/0197-0186(95)80003-4
dc.identifier.citationNeurochemistry International. Oxford: Pergamon-Elsevier B.V., v. 27, n. 6, p. 461-466, 1995.
dc.identifier.doi10.1016/0197-0186(95)00053-B
dc.identifier.issn0197-0186
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25542
dc.identifier.wosWOS:A1995TA75900002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeurochemistry International
dc.rightsAcesso restrito
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.titlePROFILE of PROSTAGLANDIN LEVELS in the RAT HIPPOCAMPUS in PILOCARPINE MODEL of EPILEPSYen
dc.typeArtigo
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