A reassessment of the hyperphagia/weight-loss paradox during sleep deprivation

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dc.contributor.authorMartins, Paulo J. F. [UNIFESP]
dc.contributor.authorD'Almeida, Vânia [UNIFESP]
dc.contributor.authorNobrega, Jose N.
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCtr Addict & Mental Hlth
dc.date.accessioned2018-06-18T12:12:05Z
dc.date.available2018-06-18T12:12:05Z
dc.date.issued2006-09-01
dc.description.abstractStudy Objectives: Sleep deprivation is a well-known paradigm to investigate the deleterious effects of prolonged wakefulness. Previous studies have shown that, during sleep deprivation, rats are hyperphagic but, paradoxically, lose body weight. This phenomenon has been attributed to increased metabolism. However, most previous studies have failed to account for food spillage, which may be considerable during sleep deprivation.Design: In the present study, we revisited the issue of feeding changes in sleep-deprived rats and introduced different procedures to allow accurate estimation of food spillage prior to, during, and after 120 hours of sleep deprivation by a single platform technique.Setting: Animal Sleep Research Laboratory, Psychobiology Department, Universidade Federal de Sao Paulo, Brazil.Measurements and Results: The main finding was that, once corrected for spillage, food intake was not significantly increased during sleep deprivation. Increases in food removed from feeders were accompanied by proportional increases in food spillage, resulting in no net changes in food intake. Further, weight loss did occur during the sleep-deprivation period, especially in the first 24 hours, and it was actually explained by a reduction in food intake.Conclusion: The hyperphagia/weight-loss paradox previously seen during prolonged sleep deprivation does not necessarily occur with shorter periods of deprivation. Although we found no evidence of hyperphagia for up to 5 days of sleep deprivation in chow-fed rats, our data suggest that an impairment in the ability to increase food intake in response to increased energy expenditure contributes to the energy deficit during sleep deprivation in rats.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, BR-04024002 Sao Paulo, Brazil
dc.description.affiliationCtr Addict & Mental Hlth, Neuroimaging Res Sect, Toronto, ON, Canada
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychobiol, BR-04024002 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1233-1238
dc.identifierhttps://doi.org/10.1093/sleep/29.9.1233
dc.identifier.citationSleep. Westchester: Amer Academy Sleep Medicine, v. 29, n. 9, p. 1233-1238, 2006.
dc.identifier.issn0161-8105
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/45629
dc.identifier.wosWOS:000240758700014
dc.language.isoeng
dc.publisherAmer Academy Sleep Medicine
dc.relation.ispartofSleep
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbody weighten
dc.subjecthyperphagiaen
dc.subjectspillageen
dc.subjectfeeding behavioren
dc.subjectraten
dc.titleA reassessment of the hyperphagia/weight-loss paradox during sleep deprivationen
dc.typeinfo:eu-repo/semantics/article
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