Visualizing the Choriocapillaris Under Drusen: Comparing 1050-nm Swept-Source Versus 840-nm Spectral-Domain Optical Coherence Tomography Angiography

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dc.citation.issue9
dc.citation.volume57
dc.contributor.authorLane, Mark
dc.contributor.authorMoult, Eric M.
dc.contributor.authorNovais, Eduardo Amorim [UNIFESP]
dc.contributor.authorLouzada, Ricardo N.
dc.contributor.authorCole, Emily D.
dc.contributor.authorLee, ByungKun
dc.contributor.authorHusvogt, Lennart
dc.contributor.authorKeane, Pearse A.
dc.contributor.authorDenniston, Alastair K.
dc.contributor.authorWitkin, Andre J.
dc.contributor.authorBaumal, Caroline R.
dc.contributor.authorFujimoto, James G.
dc.contributor.authorDuker, Jay S.
dc.contributor.authorWaheed, Nadia K.
dc.coverageRockville
dc.date.accessioned2020-07-31T12:47:43Z
dc.date.available2020-07-31T12:47:43Z
dc.date.issued2016
dc.description.abstractPURPOSE. To investigate the appearance of choriocapillaris (CC) flow under drusen by comparing long-wavelength (1050 nm) swept-source optical coherence tomography (SS-OCT) angiography with shorter-wavelength (840 nm) spectral-domain (SD) OCT angiography. METHODS. Patients with drusen imaged on both devices on the same day were selected and graded. Ambiguous OCT angiography (OCTA) signal loss was defined as low OCTA signal on the en face OCTA CC image that also had low OCT signal in the corresponding area on the en face OCT CC image and OCT B-scans. Unambiguous OCTA signal loss was defined as low OCTA signal on the en face OCTA CC image that did not have low OCT signal in the corresponding area on the en face OCT CC image and OCT B-scans. False-positive flow impairment on SS-OCTA was defined as ambiguous OCTA signal loss on SS-OCTA but no OCTA signal loss on SD-OCTA. False-positive flow impairment on SD-OCTA was defined as ambiguous OCTA signal loss on SD-OCTA but no OCTA signal loss on SS-OCTA. RESULTS. Nine eyes from seven patients were enrolled, 23 drusen were analyzed. On 840-nm SD-OCTA, 17 drusen (73.9%) exhibited OCTA signal loss. Fourteen (82.4%) were classified as ambiguous, and three (17.6%) were classified as unambiguousen
dc.description.abstract10 (58.8%) were classified as having false-positive flow impairment. On 1050-nm SS-OCTA, seven drusen (30.4%) exhibited OCTA signal loss and were classified as unambiguousen
dc.description.abstractnone were classified as having false-positive flow impairment. CONCLUSIONS. Results showed that 1050-nm SS-OCTA appears less prone to producing areas of false-positive flow impairment under drusen.en
dc.description.affiliationTufts Med Ctr, New England Eye Ctr, 260 Tremont St,Biewend 10, Boston, MA 02116 USA
dc.description.affiliationUniv Hosp Birmingham NHS Fdn Trust, Queen Elizabeth Hosp Birmingham, Birmingham, W Midlands, England
dc.description.affiliationMIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA
dc.description.affiliationMIT, Elect Res Lab, Cambridge, MA 02139 USA
dc.description.affiliationUniv Fed Sao Paulo, Sch Med, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Goias, Goiania, Go, Brazil
dc.description.affiliationUniv Erlangen Nurnberg, Pattern Recognit Lab, Erlangen, Germany
dc.description.affiliationMoorfields Eye Hosp NHS Fdn Trust, NIHR Biomed Res Ctr Ophthalmol, London, England
dc.description.affiliationUCL Inst Ophthalmol, London, England
dc.description.affiliationSandwell & West Birmingham NHS Trust, Birmingham & Midland Eye Ctr, Birmingham, W Midlands, England
dc.description.affiliationUnifespUniversidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM), São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipMacula Vision Research Foundation
dc.description.sponsorshipNational Institute for Health Research (NIH)
dc.description.sponsorshipAir Force Office of Scientific Research (AFOSR)
dc.description.sponsorshipChampalimaud Foundation
dc.description.sponsorshipMassachusetts Lions Club
dc.description.sponsorshipBirdshot Uveitis Society/Fight for Sight
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDNIH: R01-EY011289-30
dc.description.sponsorshipIDNIH: R44-EY022864-03
dc.description.sponsorshipIDNIH: R01-CA075289-19
dc.description.sponsorshipIDAFOSR: FA9550-15-1-0473
dc.description.sponsorshipIDAFOSR: FA9550-12-1-0499
dc.description.sponsorshipIDBirdshot Uveitis Society/Fight for Sight: 24BU151
dc.format.extentOCT585-OCT590
dc.identifierhttp://dx.doi.org/10.1167/iovs.15-18915
dc.identifier.citationInvestigative Ophthalmology & Visual Science. Rockville, v. 57, n. 9, p. OCT585-OCT590, 2016.
dc.identifier.doi10.1167/iovs.15-18915
dc.identifier.fileWOS000383985400063.pdf
dc.identifier.issn0146-0404
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57030
dc.identifier.wosWOS:000383985400063
dc.language.isoeng
dc.publisherAssoc Research Vision Ophthalmology Inc
dc.relation.ispartofInvestigative Ophthalmology & Visual Science
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectoptical coherence tomographyen
dc.subjectangiographyen
dc.subjectage-related macular degenerationen
dc.subjectchoriocapillarisen
dc.titleVisualizing the Choriocapillaris Under Drusen: Comparing 1050-nm Swept-Source Versus 840-nm Spectral-Domain Optical Coherence Tomography Angiographyen
dc.typeinfo:eu-repo/semantics/article
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