Gangliosides in rat femoral injury: Early effect on intimal hyperplasia

dc.contributor.authorCastro, L. C.
dc.contributor.authorMontero, EFS
dc.contributor.authorPedrosa, M. E.
dc.contributor.authorVon Kossel, K.
dc.contributor.authorSimoes, M. J.
dc.contributor.authorNigro, AJT
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:31:14Z
dc.date.available2016-01-24T12:31:14Z
dc.date.issued2001-01-01
dc.description.abstractPrevious studies demonstrated that some immunosupressive agents inhibit arterial intimal hyperplasia. Our previous studies demonstrated that gangliosides (Gang) have an immunosuppressive effect on as well as an anti-inflammatory role in the wound-healing process. Therefore, we decided to examine the effect of Gang on intimal hyperplasia, Twenty Wistar isogenic rats received a transverse division of the anterior wall of the femoral artery, followed by suturing using mononylon 10-0 under surgical microscopy and were then divided into two groups: Gang group, 3 mg/kg per day of Gang, and control group, vehicle, intramuscularly from surgery to death (1 and 3 weeks, respectively). Concentric intimal hyperplasia was observed in arteries stained by hematoxylin-eosin in control and Gang groups, However, the media layer did not demonstrate any major alterations. After 3 weeks, the Gang group showed more intimal hyperplasia than the control group. Therefore, because intimal hyperplasia worsened in the presence of Gang after 3 weeks, further studies will be necessary to clarify its role in intimal proliferation. (C) 2001 Wiley-Liss, Inc.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, UNIFESP, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, UNIFESP, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent170-172
dc.identifierhttp://dx.doi.org/10.1002/micr.1033
dc.identifier.citationMicrosurgery. New York: Wiley-liss, v. 21, n. 4, p. 170-172, 2001.
dc.identifier.doi10.1002/micr.1033
dc.identifier.issn0738-1085
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26441
dc.identifier.wosWOS:000169363700015
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofMicrosurgery
dc.rightsAcesso restrito
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.titleGangliosides in rat femoral injury: Early effect on intimal hyperplasiaen
dc.typeArtigo
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