Gangliosides in rat femoral injury: Early effect on intimal hyperplasia

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Castro, L. C.
Montero, EFS
Pedrosa, M. E.
Von Kossel, K.
Simoes, M. J.
Nigro, AJT
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Previous studies demonstrated that some immunosupressive agents inhibit arterial intimal hyperplasia. Our previous studies demonstrated that gangliosides (Gang) have an immunosuppressive effect on as well as an anti-inflammatory role in the wound-healing process. Therefore, we decided to examine the effect of Gang on intimal hyperplasia, Twenty Wistar isogenic rats received a transverse division of the anterior wall of the femoral artery, followed by suturing using mononylon 10-0 under surgical microscopy and were then divided into two groups: Gang group, 3 mg/kg per day of Gang, and control group, vehicle, intramuscularly from surgery to death (1 and 3 weeks, respectively). Concentric intimal hyperplasia was observed in arteries stained by hematoxylin-eosin in control and Gang groups, However, the media layer did not demonstrate any major alterations. After 3 weeks, the Gang group showed more intimal hyperplasia than the control group. Therefore, because intimal hyperplasia worsened in the presence of Gang after 3 weeks, further studies will be necessary to clarify its role in intimal proliferation. (C) 2001 Wiley-Liss, Inc.
Microsurgery. New York: Wiley-liss, v. 21, n. 4, p. 170-172, 2001.