What do Cochrane systematic reviews say about probiotics as preventive interventions?

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dc.citation.issue6
dc.citation.volume135
dc.contributor.authorBraga, Vinicius Lopes [UNIFESP]
dc.contributor.authordos Santos Rocha, Luana Pompeu [UNIFESP]
dc.contributor.authorBernardo, Daniel Damasceno [UNIFESP]
dc.contributor.authorCruz, Carolina de Oliveira [UNIFESP]
dc.contributor.authorRiera, Rachel [UNIFESP]
dc.coverageSao Paulo
dc.date.accessioned2020-09-01T13:21:20Z
dc.date.available2020-09-01T13:21:20Z
dc.date.issued2017
dc.description.abstractBACKGROUND: Probiotics have been used for a range of clinical situations and their use is strongly encouraged by the media worldwide. This study identified and summarized all Cochrane systematic reviews about the preventive effects of probiotics in clinical practice. DESIGN AND SETTING: Review of systematic reviews, conducted in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de Sao Paulo (Unifesp). METHODS: We included all Cochrane reviews on any probiotics when they were used as preventive interventions and compared with no intervention, placebo or any other pharmacological or non-pharmacological intervention. RESULTS: 17 Cochrane systematic reviews fulfilled our inclusion criteria and were summarized in this report. None of the reviews included in the present study provided high-quality evidence for any outcome. The benefits from use of probiotics included decreased incidence of antibiotic-associated diarrhea and Clostridium difficile-associated diarrhea; decreased incidence of upper respiratory tract infections and duration of episodes; decreased need for antibiotics and absences from school due to colds; and decreased incidence of ventilator-associated pneumonia. Probiotics seem to decrease the incidence of gestational diabetes mellitus, birthweight, risk of vaginal infection and incidence of eczema. CONCLUSION: Despite the marketing and the benefits associated with probiotics, there is little scientific evidence supporting the use of probiotics. None of the reviews provided any high-quality evidence for prevention of illnesses through use of probiotics. More trials are needed to gain better knowledge of probiotics and to confirm when their use is beneficial and cost-effective.en
dc.description.affiliationUniv Fed Sao Paulo Unifesp, EPM, Discipline Evidence Based Hlth, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo Unifesp, EPM, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo Unifesp, Evidence Based Hlth Program, Sao Paulo, Brazil
dc.description.affiliationCochrane Brazil, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, EPM, Discipline Evidence Based Hlth, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, EPM, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, Evidence Based Hlth Program, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent578-586
dc.identifierhttp://dx.doi.org/10.1590/1516-3180.2017.0310241017
dc.identifier.citationSao Paulo Medical Journal. Sao Paulo, v. 135, n. 6, p. 578-586, 2017.
dc.identifier.doi10.1590/1516-3180.2017.0310241017
dc.identifier.fileS1516-31802017000600578.pdf
dc.identifier.issn1516-3180
dc.identifier.scieloS1516-31802017000600578
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58214
dc.identifier.wosWOS:000418637300012
dc.language.isoeng
dc.publisherAssociacao Paulista Medicina
dc.relation.ispartofSao Paulo Medical Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectReview [publication type]en
dc.subjectProbioticsen
dc.subjectPreventive medicineen
dc.subjectEvidence-based medicineen
dc.subjectEvidence-based practiceen
dc.titleWhat do Cochrane systematic reviews say about probiotics as preventive interventions?en
dc.typeinfo:eu-repo/semantics/article
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