Predictors and Evolution of Antiretroviral Therapy Adherence Among Perinatally HIV-Infected Adolescents in Brazil

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dc.contributor.authorCote, Jose
dc.contributor.authorDelmas, Philippe
dc.contributor.authorde Menezes Succi, Regina Celia [UNIFESP]
dc.contributor.authorGalano, Eliana
dc.contributor.authorAuger, Patricia
dc.contributor.authorSylvain, Helene
dc.contributor.authorColson, Sebastien
dc.contributor.authorMachado, Daisy Maria [UNIFESP]
dc.date.accessioned2019-07-22T15:46:52Z
dc.date.available2019-07-22T15:46:52Z
dc.date.issued2016
dc.description.abstractPurpose: Antiretroviral therapy medication adherence is a complex phenomenon influenced by multiple factors. This study examines its evolution and predictors among perinatally HIV-infected youths in Sao Paulo, Brazil. Methods: During a 1-year longitudinal cohort study, perinatally HIV-infected youths aged 13-21 years taking antiretroviral therapy were recruited in hospitals and HIV/AIDS reference centers. Data were collected at baseline and after 12 months. Variables assessed were adherence, self-efficacy regarding medication intake, social support, stress level, depression, CD4 cell count, viral load, and symptoms. Adherence was defined as taking >= 95% of prescribed HIV medication in the past 7 days. Generalized estimating equation and analysis of variance methods were used. Results: A total of 268 adolescents participated in the study (59% femaleen
dc.description.abstractmean age of 16 years). At baseline, 63.06% of the sample was adherent to their HIV medication, and 52.99% had an undetectable viral load. All participants, regardless of adherence, reported: low levels of stress and symptoms of depressionen
dc.description.abstracthigh perception of medication self-efficacy and social supporten
dc.description.abstractand a mean of 6.8 symptoms related to their HIV medication. Predictors of adherence were: high perception of medication self-efficacy (odds ratio = 2.81en
dc.description.abstract95% confidence interval: 1.94-4.05) and low number of reported medication side effects (odds ratio = .97en
dc.description.abstract95% confidence interval: .95-.99]. Between baseline and follow-up, 49.6% remained adherent, 22.3% remained nonadherent, and the adherence level changed over time for 28.2%. Conclusions: These findings suggest the need to develop interventions to enhance self-efficacy toward medication and to help youth better manage HIV medication symptoms. Crown Copyright (C) 2016 Published by Elsevier Inc. on behalf of Society for Adolescent Health and Medicine. All rights reserved.en
dc.description.affiliationCtr Hosp Univ Montreal, Res Ctr, 850 Rue St Denis,3rd Floor,Local S03-424, Montreal, PQ H2X 0A9, Canada
dc.description.affiliationRes Chair Innovat Nursing Practices, Montreal, PQ, Canada
dc.description.affiliationUniv Montreal, Fac Nursing, Montreal, PQ, Canada
dc.description.affiliationUniv Appl Sci, Sch Nursing, La Source, Lausanne, Switzerland
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationCtr Referencia & Treinamento DST Aids, Programa Estadual Sao Paulo, Sao Paulo, Brazil
dc.description.affiliationUniv Quebec, Dept Nursing, Rimouski, PQ, Canada
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Escola Paulista Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipANRS (Agence Nationale de recherche sur le SIDA et les hepatites virales) [12238]
dc.description.sponsorshipIDANRS: 12238
dc.format.extent305-310
dc.identifierhttp://dx.doi.org/10.1016/j.jadohealth.2016.05.004
dc.identifier.citationJournal Of Adolescent Health. New York, v. 59, n. 3, p. 305-310, 2016.
dc.identifier.doi10.1016/j.jadohealth.2016.05.004
dc.identifier.issn1054-139X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51131
dc.identifier.wosWOS:000382312300012
dc.language.isoeng
dc.publisherElsevier Science Inc
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectHIVen
dc.subjectHIV medicationen
dc.subjectMedication adherenceen
dc.subjectAdolescentsen
dc.subjectPerinatally HIV-infected adolescentsen
dc.subjectStressen
dc.subjectDepressionen
dc.subjectSelf-efficacyen
dc.subjectSocial supporten
dc.subjectSide effectsen
dc.titlePredictors and Evolution of Antiretroviral Therapy Adherence Among Perinatally HIV-Infected Adolescents in Brazilen
dc.typeinfo:eu-repo/semantics/article
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