The Impact of Healthy Parenting As a Protective Factor for Posttraumatic Stress Disorder in Adulthood: A Case-Control Study

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dc.contributor.authorLima, Adriano R. [UNIFESP]
dc.contributor.authorMello, Marcelo Feijó de [UNIFESP]
dc.contributor.authorAndreoli, Sergio Baxter [UNIFESP]
dc.contributor.authorFossaluza, Victor
dc.contributor.authorAraujo, Celia M. de [UNIFESP]
dc.contributor.authorJackowski, Andrea Parolin [UNIFESP]
dc.contributor.authorBressan, Rodrigo Affonseca [UNIFESP]
dc.contributor.authorMari, Jair de Jesus. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:35:10Z
dc.date.available2016-01-24T14:35:10Z
dc.date.issued2014-01-29
dc.description.abstractBackground: Early life social adversity can influence stress response mechanisms and is associated with anxious behaviour and reductions in callosal area later in life.Objective: To evaluate the association between perceptions of parental bonding in childhood/adolescence, hypothalamic-pituitary-adrenal (HPA) axis response, and callosal structural integrity in adult victims of severe urban violence with and without PTSD.Methods: Seventy-one individuals with PTSD and 62 without the disorder were assessed with the Parental Bonding Instrument (PBI). the prednisolone suppression test was administered to assess cortisol levels, and magnetic resonance imaging was used to assess the total area of the corpus callosum (CC), as well as the areas of callosal subregions.Results: the PBI items related to the perception of 'not having a controlling mother' (OR 4.84; 95% CI [2.26-10.3]; p = 0.01), 'having a caring father' (OR 2.46; 95'% CI [1.18-5.12]; p = 0.02), and 'not having controlling parents' (OR 2.70; 95% CI [1.10-6.63]; p = 0.04) were associated with a lower risk of PTSD. the PTSD group showed a blunted response to the prednisolone suppression test, with lower salivary cortisol levels upon waking up (p = 0.03). Individuals with PTSD had smaller total CC area than those without the disorder, but these differences were not statistically significant (e-value = 0.34).Conclusions: Healthy parental bonding, characterized by the perception of low parental control and high affection, were associated with a lower risk of PTSD in adulthood, suggesting that emotional enrichment and the encouragement of autonomy are protective against PTSD in adulthood.en
dc.description.affiliationFed Univ São Paulo UNIFESP, São Paulo Sch Med, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Math & Stat, BR-09500900 São Paulo, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, Interdisciplinary Lab Clin Neurosci LiNC, São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, São Paulo Sch Med, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Interdisciplinary Lab Clin Neurosci LiNC, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Research Council (CNP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDNational Research Council (CNP): 420122/2005-2
dc.description.sponsorshipIDFAPESP: 2004/15039-0
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0087117
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 9, n. 1, 9 p., 2014.
dc.identifier.doi10.1371/journal.pone.0087117
dc.identifier.fileWOS000330570000105.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37332
dc.identifier.wosWOS:000330570000105
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleThe Impact of Healthy Parenting As a Protective Factor for Posttraumatic Stress Disorder in Adulthood: A Case-Control Studyen
dc.typeinfo:eu-repo/semantics/article
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