Urinary 6-Sulphatoxymelatonin Levels Are Depressed in Chronic Migraine and Several Comorbidities

dc.contributor.authorMasruha, Marcelo R. [UNIFESP]
dc.contributor.authorLin, Jaime [UNIFESP]
dc.contributor.authorSouza Vieira, Domingos S. de
dc.contributor.authorMinett, Thais S. C. [UNIFESP]
dc.contributor.authorCipolla-Neto, Jose
dc.contributor.authorZukerman, Eliova
dc.contributor.authorVilanova, Luiz C. P. [UNIFESP]
dc.contributor.authorPeres, Mario F. P. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Israelita Albert Einstein
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T13:59:27Z
dc.date.available2016-01-24T13:59:27Z
dc.date.issued2010-03-01
dc.description.abstractObjective.-To assess urinary 6-sulphatoxymelatonin levels in a large consecutive series of patients with migraine and several comorbidities (chronic fatigue, fibromyalgia, insomnia, anxiety, and depression) as compared with controls.Background.-Urine analysis is widely used as a measure of melatonin secretion, as it is correlated with the nocturnal profile of plasma melatonin secretion. Melatonin has critical functions in human physiology and substantial evidence points to its importance in the regulation of circadian rhythms, sleep, and headache disorders.Methods.-Urine samples were collected into a single plastic container over a 12-hour period from 8:00 pm to 8:00 am of the next day, and 6-sulphatoxymelatonin was measured by quantitative ELISA. All of the patients were given a detailed questionnaire about headaches and additionally answered the following questionnaires: Chalder fatigue questionnaire, Epworth somnolence questionnaire, State-Trait Anxiety Inventory, and the Beck Depression Inventory.Results.-A total of 220 subjects were evaluated - 73 (33%) had episodic migraine, 73 (33%) had chronic migraine, and 74 (34%) were enrolled as control subjects. There was a strong correlation between the concentration of 6-sulphatoxymelatonin detected and chronic migraine. Regarding the comorbidities, this study objectively demonstrates an inverse relationship between 6-sulphatoxymelatonin levels and depression, anxiety, and fatigue.Conclusions.-To our knowledge, this is the first study to evaluate the relationship between the urinary concentration of melatonin and migraine comorbidities. These results support hypothalamic involvement in migraine pathophysiology.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Inst Ensino & Pesquisa, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Prevent Med, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Dept Physiol & Biophys, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Prevent Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent413-419
dc.identifierhttp://dx.doi.org/10.1111/j.1526-4610.2009.01547.x
dc.identifier.citationHeadache. Malden: Wiley-Blackwell Publishing, Inc, v. 50, n. 3, p. 413-419, 2010.
dc.identifier.doi10.1111/j.1526-4610.2009.01547.x
dc.identifier.issn0017-8748
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32372
dc.identifier.wosWOS:000275097400008
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofHeadache
dc.rightsAcesso restrito
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectpathophysiologyen
dc.subjecthypothalamusen
dc.subjectmelatoninen
dc.subjectmigraineen
dc.subjectcomorbiditiesen
dc.titleUrinary 6-Sulphatoxymelatonin Levels Are Depressed in Chronic Migraine and Several Comorbiditiesen
dc.typeArtigo
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