Antioxidant vitamins C and E supplementation increases markers of haemolysis in sickle cell anaemia patients: a randomized, double-blind, placebo-controlled trial

dc.contributor.authorArruda, Martha M. [UNIFESP]
dc.contributor.authorMecabo, Grazielle [UNIFESP]
dc.contributor.authorRodrigues, Celso A. [UNIFESP]
dc.contributor.authorMatsuda, Sandra S. [UNIFESP]
dc.contributor.authorRabelo, Iara B. [UNIFESP]
dc.contributor.authorFigueiredo, Maria S. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:31:18Z
dc.date.available2016-01-24T14:31:18Z
dc.date.issued2013-03-01
dc.description.abstractErythrocytes from sickle cell anaemia (SCA) patients continuously produce larger amounts of pro-oxidants than normal cells. Oxidative stress seems to primarily affect the membrane and results in haemolysis. the use of antioxidants in vitro reduces the generation of pro-oxidants. To evaluate the impact of vitamins C (VitC) and E (VitE) supplementation in SCA patients, patients over 18years were randomly assigned to receive VitC 1400mg+VitE 800mg per day or placebo orally for 180d. Eighty-three patients were enrolled (44 vitamins, 39 placebo), median age 27 (1868) years, 64% female. There were no significant differences between the two groups regarding clinical complications or baseline laboratorial tests. Sixty percent of the patients were VitC deficient, 70% were VitE deficient. Supplementation significantly increased serum VitC and E. However, no significant changes in haemoglobin levels were observed, and, unexpectedly, there was a significant increase in haemolytic markers with vitamin supplementation. in conclusion, VitC+VitE supplementation did not improve anaemia and, surprisingly, increased markers of haemolysis in patients with SCA and S-0-thalassaemia. the exact mechanisms to explain this findings and their clinical significance remain to be determined.en
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, Hematol & Blood Transfus Dept, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, Hematol & Blood Transfus Dept, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 2010/02933-6
dc.description.sponsorshipIDCNPq: 140392/2009-2
dc.format.extent688-700
dc.identifierhttp://dx.doi.org/10.1111/bjh.12185
dc.identifier.citationBritish Journal of Haematology. Hoboken: Wiley-Blackwell, v. 160, n. 5, p. 688-700, 2013.
dc.identifier.doi10.1111/bjh.12185
dc.identifier.issn0007-1048
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36003
dc.identifier.wosWOS:000315092200014
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofBritish Journal of Haematology
dc.rightsAcesso aberto
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectsickle cell anaemiaen
dc.subjectoxidative stressen
dc.subjecthaemolysisen
dc.subjectvitamin Cen
dc.subjectvitamin Een
dc.titleAntioxidant vitamins C and E supplementation increases markers of haemolysis in sickle cell anaemia patients: a randomized, double-blind, placebo-controlled trialen
dc.typeArtigo
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