Injury switches melatonin production source from endocrine (pineal) to paracrine (phagocytes) - melatonin in human colostrum and colostrum phagocytes

Página do item simplificado
dc.contributor.authorPontes, Gerlandia N.
dc.contributor.authorCardoso, Elaine C.
dc.contributor.authorCarneiro-Sampaio, Magda M. S.
dc.contributor.authorMarkus, Regina P.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:41:28Z
dc.date.available2016-01-24T12:41:28Z
dc.date.issued2006-09-01
dc.description.abstractA large number of data show that melatonin has immunomodulatory properties and is produced by immunocompetent cells; also, some evidence suggests a 'feedback' of the activated immune system on the pineal gland. in this paper, we studied immune-pineal interactions in colostrum obtained from healthy puerperae and mothers with mastitis taking into account that, (a) melatonin levels in milk reflects pineal activity and (b) colostrum quiescent mononuclear and polymorphonuclear phagocytes from healthy mothers in culture are adequate for evaluating the ability of immunocompetent cells to produce melatonin. Here we compared the diurnal and nocturnal melatonin levels in colostrum from healthy puerperae and mothers with mastitis; this is a unique noninvasive model for determining pineal activity in the proinflammatory phase of a defense response. in addition, we determined the 'in vitro' production of melatonin by colostrum immunocompetent cells stimulated by enteropathogenic Escherichia coli or zymosan. Suppression of nocturnal melatonin rise in mothers with mastitis was highly correlated with increased tumor necrosis factor-alpha (TNF-alpha) secretion. This result, interpreted taking into account the presence of the transcription factor nuclear factor kappa B in pineal gland, suggest that the proinflammatory cytokine can inhibit nocturnal pineal melatonin production. On the other hand, stimulated, but not quiescent, immunocompetent cells secreted in the colostrum produced melatonin in vitro. in addition, this production ceases after bacteria killing. These results suggest that during the response to an injury the production of melatonin can be transiently shifted from an endocrine (pineal) to a paracrine (immunocompetent cells) source.en
dc.description.affiliationUniv São Paulo, Inst Biociencias, Dept Fisiol, Lab Chronopharmacol, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Inst Biomed Sci, Dept Immunol,Lab Mucosal Immunol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Dept Pediat, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent136-141
dc.identifierhttp://dx.doi.org/10.1111/j.1600-079X.2006.00345.x
dc.identifier.citationJournal of Pineal Research. Oxford: Blackwell Publishing, v. 41, n. 2, p. 136-141, 2006.
dc.identifier.doi10.1111/j.1600-079X.2006.00345.x
dc.identifier.issn0742-3098
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29150
dc.identifier.wosWOS:000239371000007
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofJournal of Pineal Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectcolostrumen
dc.subjectenteropathogenic Escherichia colien
dc.subjectmastitisen
dc.subjectmelatoninen
dc.subjectphagocytosisen
dc.subjecttumor necrosis factor-alphaen
dc.subjectzymosanen
dc.titleInjury switches melatonin production source from endocrine (pineal) to paracrine (phagocytes) - melatonin in human colostrum and colostrum phagocytesen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
Em verificação - Geral